Giuseppe
Emeritus
Replacement of Sublineages of Avian Influenza (H5N1) by Reassortments, Sub-Saharan Africa [US CDC EID]
DOI: 10.3201/eid1411.080555
Suggested citation for this article: Owoade AA, Gerloff NA, Ducatez MF, Taiwo JO, Kremer JR, Muller CP. Highly pathogenic avian influenza (H5N1), sub-Saharan Africa. Emerg Infect Dis. 2008 Nov; [Epub ahead of print]
Replacement of Sublineages of Avian Influenza (H5N1) by Reassortments, Sub-Saharan Africa
Ademola A. Owoade,1 Nancy A. Gerloff,1 Mariette F. Ducatez,2 Jolaoso O. Taiwo, Jacques R. Kremer, and Claude P. Muller - Author affiliations: University of Ibadan, Ibadan, Nigeria (A.A. Owoade); National Public Health Laboratory, Luxembourg (N.A. Gerloff, M.F. Ducatez, J.R. Kremer, C.P. Muller); and Ogun State Ministry of Agriculture, Abeokuta, Nigeria (J.O. Taiwo)
1These authors contributed equally to this article. 2Current affiliation: St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Eight new full-length sequences from highly pathogenic avian influenza (H5N1) viruses from 4 states in southwest Nigeria were analyzed.
All gene sequences were more closely related to the first strains found in Nigeria in 2006 than to any strain found outside the country.
Six viruses had evolved by at least 3 reassortment events (AC HA/NS, AC NS) from previously identified sublineages A (EMA 2) and C (EMA 1).
Our results suggest that highly pathogenic avian influenza (H5N1) viruses initially imported into Nigeria in 2006 have been gradually replaced by various reassortments.
In all reassortants, nonstructural genes were derived from sublineage C with 2 characteristic amino acids (compared with sublineage A).
If the high prevalence of reassortants was typical for West Africa in 2007, the absence of such reassortants anywhere else suggests that reintroductions of influenza A (H5N1) from Africa into Eurasia must be rare.
Original text at: http://www.cdc.gov/eid/content/14/11/pdfs/08-0555.pdf
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DOI: 10.3201/eid1411.080555
Suggested citation for this article: Owoade AA, Gerloff NA, Ducatez MF, Taiwo JO, Kremer JR, Muller CP. Highly pathogenic avian influenza (H5N1), sub-Saharan Africa. Emerg Infect Dis. 2008 Nov; [Epub ahead of print]
Replacement of Sublineages of Avian Influenza (H5N1) by Reassortments, Sub-Saharan Africa
Ademola A. Owoade,1 Nancy A. Gerloff,1 Mariette F. Ducatez,2 Jolaoso O. Taiwo, Jacques R. Kremer, and Claude P. Muller - Author affiliations: University of Ibadan, Ibadan, Nigeria (A.A. Owoade); National Public Health Laboratory, Luxembourg (N.A. Gerloff, M.F. Ducatez, J.R. Kremer, C.P. Muller); and Ogun State Ministry of Agriculture, Abeokuta, Nigeria (J.O. Taiwo)
1These authors contributed equally to this article. 2Current affiliation: St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Eight new full-length sequences from highly pathogenic avian influenza (H5N1) viruses from 4 states in southwest Nigeria were analyzed.
All gene sequences were more closely related to the first strains found in Nigeria in 2006 than to any strain found outside the country.
Six viruses had evolved by at least 3 reassortment events (AC HA/NS, AC NS) from previously identified sublineages A (EMA 2) and C (EMA 1).
Our results suggest that highly pathogenic avian influenza (H5N1) viruses initially imported into Nigeria in 2006 have been gradually replaced by various reassortments.
In all reassortants, nonstructural genes were derived from sublineage C with 2 characteristic amino acids (compared with sublineage A).
If the high prevalence of reassortants was typical for West Africa in 2007, the absence of such reassortants anywhere else suggests that reintroductions of influenza A (H5N1) from Africa into Eurasia must be rare.
Original text at: http://www.cdc.gov/eid/content/14/11/pdfs/08-0555.pdf
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