Emily
Editor, Senior Moderator
https://www.tandfonline.com/doi/full/10.1080/14760584.2022.2071705
Md Anwarul Azim Majumder & Mohammed S. Razzaque (2022) Repeated vaccination and ‘vaccine exhaustion’: relevance to the COVID-19 crisis, Expert Review of Vaccines, DOI: 10.1080/14760584.2022.2071705
Vaccines protect recipients by eliciting immune responses and communities by reducing transmission of infection. However, newer strains with markedly increased transmissibility have frustrated efforts to control the spread of COVID-19. The Omicron BA.1 and BA.2 variants of SARS-CoV-2 are examples of rapidly evolving new strains. The overuse of antimicrobial drugs frequently induces drug resistance. The potential for repeated vaccination to cause vaccine exhaustion and, consequently, reduce protection against microbial infection merits further study. Existing studies have identified microbial evolution, immune suppression, immune evasion, and repeated vaccination as probable causes of vaccine resistance. Emerging recommendations for repeated vaccination against COVID-19 have raised concern that boosr doses could contribute to viral mutations leading to longer-term vaccine resistance....
Md Anwarul Azim Majumder & Mohammed S. Razzaque (2022) Repeated vaccination and ‘vaccine exhaustion’: relevance to the COVID-19 crisis, Expert Review of Vaccines, DOI: 10.1080/14760584.2022.2071705
Vaccines protect recipients by eliciting immune responses and communities by reducing transmission of infection. However, newer strains with markedly increased transmissibility have frustrated efforts to control the spread of COVID-19. The Omicron BA.1 and BA.2 variants of SARS-CoV-2 are examples of rapidly evolving new strains. The overuse of antimicrobial drugs frequently induces drug resistance. The potential for repeated vaccination to cause vaccine exhaustion and, consequently, reduce protection against microbial infection merits further study. Existing studies have identified microbial evolution, immune suppression, immune evasion, and repeated vaccination as probable causes of vaccine resistance. Emerging recommendations for repeated vaccination against COVID-19 have raised concern that boosr doses could contribute to viral mutations leading to longer-term vaccine resistance....