tetano
Editor, Senior Moderator
NPJ Vaccines. 2019 Jul 9;4:28. doi: 10.1038/s41541-019-0123-7. eCollection 2019.
[h=1]Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets.[/h] Music N[SUP]1,[/SUP][SUP]2[/SUP], Tzeng WP[SUP]1[/SUP], Liaini Gross F[SUP]1[/SUP], Levine MZ[SUP]1[/SUP], Xu X[SUP]1[/SUP], Shieh WJ[SUP]3[/SUP], Tumpey TM[SUP]1[/SUP], Katz JM[SUP]1[/SUP], York IA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season only. To better understand potential mechanisms underlying these observations, we vaccinated influenza-naive ferrets either twice, 10 months apart (repeated vaccination group; RV), or once (current season only group; CS), using a prime-boost regimen, and then challenged the ferrets with A/Hong Kong/4801/2014(H3N2). Ferrets that received either vaccine regimen were protected against influenza disease and infection relative to naive unvaccinated ferrets, but the RV group shed more virus, especially at the peak of virus shedding 2 days post infection (p < 0.001) and regained weight more slowly (p < 0.05) than those in the CS group. Qualitative, rather than quantitative, differences in the antibody response may affect protection after repeated influenza vaccination.
[h=4]KEYWORDS:[/h] Adaptive immunity; Influenza virus; Vaccines
PMID: 31312528 PMCID: PMC6616337 DOI: 10.1038/s41541-019-0123-7
Free PMC Article
[h=1]Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets.[/h] Music N[SUP]1,[/SUP][SUP]2[/SUP], Tzeng WP[SUP]1[/SUP], Liaini Gross F[SUP]1[/SUP], Levine MZ[SUP]1[/SUP], Xu X[SUP]1[/SUP], Shieh WJ[SUP]3[/SUP], Tumpey TM[SUP]1[/SUP], Katz JM[SUP]1[/SUP], York IA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season only. To better understand potential mechanisms underlying these observations, we vaccinated influenza-naive ferrets either twice, 10 months apart (repeated vaccination group; RV), or once (current season only group; CS), using a prime-boost regimen, and then challenged the ferrets with A/Hong Kong/4801/2014(H3N2). Ferrets that received either vaccine regimen were protected against influenza disease and infection relative to naive unvaccinated ferrets, but the RV group shed more virus, especially at the peak of virus shedding 2 days post infection (p < 0.001) and regained weight more slowly (p < 0.05) than those in the CS group. Qualitative, rather than quantitative, differences in the antibody response may affect protection after repeated influenza vaccination.
[h=4]KEYWORDS:[/h] Adaptive immunity; Influenza virus; Vaccines
PMID: 31312528 PMCID: PMC6616337 DOI: 10.1038/s41541-019-0123-7
Free PMC Article