tetano
Editor, Senior Moderator
Ren Fail
. 2020 Nov;42(1):726-732.
doi: 10.1080/0886022X.2020.1796705.
Clinical characteristics of 31 hemodialysis patients with 2019 novel coronavirus: a retrospective study
Jiong Zhang[SUP] 1 [/SUP], Fang Cao[SUP] 2 [/SUP], Shu-Kun Wu[SUP] 1 [/SUP], Lu Xiang-Heng[SUP] 3 [/SUP], Wei Li[SUP] 4 [/SUP], Gui-Sen Li[SUP] 1 [/SUP], Jia Wang[SUP] 5 [/SUP]
Affiliations
Abstract
Aim: Novel coronavirus pneumonia (COVID-19) has become pandemic. It brings serious threat to hemodialysis (HD) patients. Therefore, we carried out a study on the clinical characteristics of HD patients with COVID-19.
Methods: We retrospectively analyzed the data of 31 HD patients with COVID-19. The clinical features of patients include epidemiology, clinical symptoms, laboratory and imaging test, treatment and prognosis.
Results: 61.3% were severe, and 38.7% were mild. 83.9% had a close contact history with COVID-19 patients. The average age was 62.3 years comprising of 58.1% men and 41.9% women. Ninety percent had chronic diseases except ESRD. Clinical symptoms include cough (85%), fever (43%), and shortness of breath (48.4%), etc. Complications included ARDS (25.8%), AHF (22.6%), and septic shock (16.1%), etc. 64.5% of patients had remission, and 35.5% of patients had no remission with 6.5% deaths. Compared with the baseline before infection, HD patients with COVID-19 had lower lymphocytes, albumin and glucose, and higher D-dimer, albumin, phosphorus, lactate dehydrogenase, and CRP. There was no significant correlation between the neutrophils/lymphocytes ratio and the severity of the disease.
Conclusions: Compared with the reported general population, the HD patients are susceptible to COVID-19 infection, especially older men and those with other underlying diseases. Moreover, HD patients have more severe infection and inflammation with less symptoms and worse outcome. COVID-19 infection can cause dialysis patients lower immunity, stronger inflammation, malnutrition, and internal environment disorder. Neutrophils/lymphocytes ratio does not reflect the severity of the HD patients with COVID-19.
Keywords: COVID-19; Hemodialysis; chronic inflammation; clinical characteristics; epidemiology.
. 2020 Nov;42(1):726-732.
doi: 10.1080/0886022X.2020.1796705.
Clinical characteristics of 31 hemodialysis patients with 2019 novel coronavirus: a retrospective study
Jiong Zhang[SUP] 1 [/SUP], Fang Cao[SUP] 2 [/SUP], Shu-Kun Wu[SUP] 1 [/SUP], Lu Xiang-Heng[SUP] 3 [/SUP], Wei Li[SUP] 4 [/SUP], Gui-Sen Li[SUP] 1 [/SUP], Jia Wang[SUP] 5 [/SUP]
Affiliations
- PMID: 32722980
- DOI: 10.1080/0886022X.2020.1796705
Abstract
Aim: Novel coronavirus pneumonia (COVID-19) has become pandemic. It brings serious threat to hemodialysis (HD) patients. Therefore, we carried out a study on the clinical characteristics of HD patients with COVID-19.
Methods: We retrospectively analyzed the data of 31 HD patients with COVID-19. The clinical features of patients include epidemiology, clinical symptoms, laboratory and imaging test, treatment and prognosis.
Results: 61.3% were severe, and 38.7% were mild. 83.9% had a close contact history with COVID-19 patients. The average age was 62.3 years comprising of 58.1% men and 41.9% women. Ninety percent had chronic diseases except ESRD. Clinical symptoms include cough (85%), fever (43%), and shortness of breath (48.4%), etc. Complications included ARDS (25.8%), AHF (22.6%), and septic shock (16.1%), etc. 64.5% of patients had remission, and 35.5% of patients had no remission with 6.5% deaths. Compared with the baseline before infection, HD patients with COVID-19 had lower lymphocytes, albumin and glucose, and higher D-dimer, albumin, phosphorus, lactate dehydrogenase, and CRP. There was no significant correlation between the neutrophils/lymphocytes ratio and the severity of the disease.
Conclusions: Compared with the reported general population, the HD patients are susceptible to COVID-19 infection, especially older men and those with other underlying diseases. Moreover, HD patients have more severe infection and inflammation with less symptoms and worse outcome. COVID-19 infection can cause dialysis patients lower immunity, stronger inflammation, malnutrition, and internal environment disorder. Neutrophils/lymphocytes ratio does not reflect the severity of the HD patients with COVID-19.
Keywords: COVID-19; Hemodialysis; chronic inflammation; clinical characteristics; epidemiology.