Mary Wilson
Well-known member
Published: 26 September 2022
https://doi.org/10.1093/cid/ciac769
John I Hogan, MD, Ralf Duerr, MD, PhD, Dacia Dimartino, PhD, Christian Marier, Sarah E Hochman, MD, Sapna Mehta, MD, Guiqing Wang, MD, Adriana Heguy, PhD
Abstract
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
https://watermark.silverchair.com/c...IujJt1cYv17WNsR80gRC6WYgy8ahsnE-4pZOxRgYR7arL
https://doi.org/10.1093/cid/ciac769
John I Hogan, MD, Ralf Duerr, MD, PhD, Dacia Dimartino, PhD, Christian Marier, Sarah E Hochman, MD, Sapna Mehta, MD, Guiqing Wang, MD, Adriana Heguy, PhD
Abstract
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
https://watermark.silverchair.com/c...IujJt1cYv17WNsR80gRC6WYgy8ahsnE-4pZOxRgYR7arL