tetano
Editor, Senior Moderator
Nat Rev Immunol. 2012 Mar 9. doi: 10.1038/nri3166. [Epub ahead of print]
Regulating the adaptive immune response to respiratory virus infection.
Braciale TJ, Sun J, Kim TS.
Source
1] Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA. [2] Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA. [3] Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA. [4].
Abstract
Recent years have seen several advances in our understanding of immunity to virus infection of the lower respiratory tract, including to influenza virus infection. Here, we review the cellular targets of viruses and the features of the host immune response that are unique to the lungs. We describe the interplay between innate and adaptive immune cells in the induction, expression and control of antiviral immunity, and discuss the impact of the infected lung milieu on moulding the response of antiviral effector T cells. Recent findings on the mechanisms that underlie the increased frequency of severe pulmonary bacterial infections following respiratory virus infection are also discussed.
PMID:
22402670
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22402670
Regulating the adaptive immune response to respiratory virus infection.
Braciale TJ, Sun J, Kim TS.
Source
1] Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA. [2] Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA. [3] Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA. [4].
Abstract
Recent years have seen several advances in our understanding of immunity to virus infection of the lower respiratory tract, including to influenza virus infection. Here, we review the cellular targets of viruses and the features of the host immune response that are unique to the lungs. We describe the interplay between innate and adaptive immune cells in the induction, expression and control of antiviral immunity, and discuss the impact of the infected lung milieu on moulding the response of antiviral effector T cells. Recent findings on the mechanisms that underlie the increased frequency of severe pulmonary bacterial infections following respiratory virus infection are also discussed.
PMID:
22402670
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22402670