Mary Wilson
Well-known member
Science 09 Oct 2020:
eabe2402
DOI: 10.1126/science.abe2402
Alina Baum[SUP]1[/SUP], Dharani Ajithdoss[SUP]1[/SUP], Richard Copin[SUP]1[/SUP], Anbo Zhou[SUP]1[/SUP], Kathryn Lanza[SUP]1[/SUP], Nicole Negron[SUP]1[/SUP], Min Ni[SUP]1[/SUP], Yi Wei[SUP]1[/SUP], Kusha Mohammadi[SUP]1[/SUP], Bret Musser[SUP]1[/SUP], Gurinder S. Atwal[SUP]1[/SUP], Adelekan Oyejide[SUP]1[/SUP], Yenny Goez-Gazi[SUP]2[/SUP], John Dutton[SUP]2[/SUP], Elizabeth Clemmons[SUP]2[/SUP], Hilary M. Staples[SUP]2[/SUP], Carmen Bartley[SUP]2[/SUP], Benjamin Klaffke[SUP]2[/SUP], Kendra Alfson[SUP]2[/SUP], Michal Gazi[SUP]2[/SUP], Olga Gonzalez[SUP]2[/SUP], Edward Dick Jr.[SUP]2[/SUP], Ricardo Carrion Jr.[SUP]2[/SUP], Laurent Pessaint[SUP]3[/SUP], Maciel Porto[SUP]3[/SUP], Anthony Cook[SUP]3[/SUP], Renita Brown[SUP]3[/SUP], Vaneesha Ali[SUP]3 [/SUP]Jack Greenhouse[SUP]3[/SUP], Tammy Taylor[SUP]3[/SUP], Hanne Andersen[SUP]3[/SUP], Mark G. Lewis[SUP]3[/SUP], Neil Stahl[SUP]1[/SUP], Andrew J. Murphy[SUP]1[/SUP], George D. Yancopoulos[SUP]1[/SUP], Christos A. Kyratsous[SUP]1[/SUP],*
Abstract
An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in lower and upper airways and decrease virus induced pathological sequalae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.
https://science.sciencemag.org/content/early/2020/10/08/science.abe2402
eabe2402
DOI: 10.1126/science.abe2402
Alina Baum[SUP]1[/SUP], Dharani Ajithdoss[SUP]1[/SUP], Richard Copin[SUP]1[/SUP], Anbo Zhou[SUP]1[/SUP], Kathryn Lanza[SUP]1[/SUP], Nicole Negron[SUP]1[/SUP], Min Ni[SUP]1[/SUP], Yi Wei[SUP]1[/SUP], Kusha Mohammadi[SUP]1[/SUP], Bret Musser[SUP]1[/SUP], Gurinder S. Atwal[SUP]1[/SUP], Adelekan Oyejide[SUP]1[/SUP], Yenny Goez-Gazi[SUP]2[/SUP], John Dutton[SUP]2[/SUP], Elizabeth Clemmons[SUP]2[/SUP], Hilary M. Staples[SUP]2[/SUP], Carmen Bartley[SUP]2[/SUP], Benjamin Klaffke[SUP]2[/SUP], Kendra Alfson[SUP]2[/SUP], Michal Gazi[SUP]2[/SUP], Olga Gonzalez[SUP]2[/SUP], Edward Dick Jr.[SUP]2[/SUP], Ricardo Carrion Jr.[SUP]2[/SUP], Laurent Pessaint[SUP]3[/SUP], Maciel Porto[SUP]3[/SUP], Anthony Cook[SUP]3[/SUP], Renita Brown[SUP]3[/SUP], Vaneesha Ali[SUP]3 [/SUP]Jack Greenhouse[SUP]3[/SUP], Tammy Taylor[SUP]3[/SUP], Hanne Andersen[SUP]3[/SUP], Mark G. Lewis[SUP]3[/SUP], Neil Stahl[SUP]1[/SUP], Andrew J. Murphy[SUP]1[/SUP], George D. Yancopoulos[SUP]1[/SUP], Christos A. Kyratsous[SUP]1[/SUP],*
Abstract
An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in lower and upper airways and decrease virus induced pathological sequalae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.
https://science.sciencemag.org/content/early/2020/10/08/science.abe2402