Recovery of a Multidrug-Resistant Strain of Pandemic Influenza A 2009 (H1N1) Virus Carrying a Dual H275Y/I223R Mutation from a Child after Prolonged T

[tetano]

Clin Infect Dis. 2010 Oct 15;51(8):983-984.
Recovery of a Multidrug-Resistant Strain of Pandemic Influenza A 2009 (H1N1) Virus Carrying a Dual H275Y/I223R Mutation from a Child after Prolonged Treatment with Oseltamivir.

Nguyen HT, Fry AM, Loveless PA, Klimov AI, Gubareva LV.

Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and 2Division of Infectious Disease Epidemiology, Pennsylvania Department of Health, Reading, Pennsylvania.

PMID: 20858074 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/20858074

 

[mixin]

Re: Recovery of a Multidrug-Resistant Strain of Pandemic Influenza A 2009 (H1N1) Virus Carrying a Dual H275Y/I223R Mutation from a Child after Prolonged Treatment with Oseltamivir

All I could find was pay to view and no abstract.

 

[tetano]

Re: Recovery of a Multidrug-Resistant Strain of Pandemic Influenza A 2009 (H1N1) Virus Carrying a Dual H275Y/I223R Mutation from a Child after Prolonged Treatment with Oseltamivir

Here it is:

Multidrug-resistant 2009 H1N1 virus reported in teenager
A 2009 H1N1 flu virus that contributed to the death of a 14-year-old girl was resistant to three neuraminidase inhibitors, pointing up the need for new types of antivirals, according to a letter in the Oct 15 Clinical Infectious Diseases (CID). The girl, who had systemic lupus erythematosus and other illnesses, was hospitalized with respiratory failure in October 2009. She was first treated with oseltamivir (Tamiflu) for several weeks and later with intravenous zanamivir (Relenza), but she died of complications in late December. Testing of samples taken in November showed that the virus was highly resistant to oseltamivir. It also showed evidence of resistance to peramivir and zanamivir, though to much lower degrees. Sequencing of the virus showed its neuraminidase protein contained two mutations: H275Y, which is known to confer resistance to oseltamivir but not zanamivir, and I223R. In one previous case, the I223R mutation alone was associated with slight resistance to oseltamivir and peramivir, the report says. Compared with strains featuring either mutation alone, the "dual mutant I223R/H275Y" showed greater resistance. "The potential for emergence of viruses resistant to multiple neuraminidase inhibitors reinforces efforts to develop drugs with a different mechanism of action," the report states.
Oct 15 CID letter

http://www.cidrap.umn.edu//cidrap/content/influenza/swineflu/news/sep2310h1n1scan.html

 

[mixin]

Re: Recovery of a Multidrug-Resistant Strain of Pandemic Influenza A 2009 (H1N1) Virus Carrying a Dual H275Y/I223R Mutation from a Child after Prolonged Treatment with Oseltamivir

Thanks for finding that.

The poor girl; that was a lot of health problems for a 14 year old to have to deal with.

Systemic lupus erythematosus (SLE) is a chronic, inflammatory
autoimmune disorder. It may affect the skin, joints, kidneys, and
other organs.