tetano
Editor, Senior Moderator
Virus Res. 2013 Dec 31. pii: S0168-1702(13)00478-4. doi: 10.1016/j.virusres.2013.12.032. [Epub ahead of print]
Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo.
Hillaire ML1, van Eijk M2, Trierum SE1, Fouchier RA1, Osterhaus AD3, Haagsman HP2, Rimmelzwaan GF3.
Author information
Abstract
Influenza is a major burden to public health. Due to high mutation rates and selection pressure, mutant viruses emerge which are resistant to currently used antiviral drugs. Therefore, there is a need for the development of novel classes of antiviral drugs that suffer less from the emergence of resistant viruses. Antiviral drugs based on collectin-like surfactant protein D (SP-D) may fulfil these requirements. Especially porcine SP-D displays strong antiviral activity to influenza A viruses. In the present study the antiviral activity of recombinant porcine SP-D was investigated in ex vivo cultures of respiratory tract tissue infected with human influenza A virus of the H3N2 subtype. Porcine SP-D has antiviral activity in these test systems. It is suggested that porcine SP-D may be used as a venue to develop a novel class of antiviral drugs.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
antiviral activity, influenza A virus, porcine surfactant protein D
PMID:
24389095
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24389095
Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo.
Hillaire ML1, van Eijk M2, Trierum SE1, Fouchier RA1, Osterhaus AD3, Haagsman HP2, Rimmelzwaan GF3.
Author information
Abstract
Influenza is a major burden to public health. Due to high mutation rates and selection pressure, mutant viruses emerge which are resistant to currently used antiviral drugs. Therefore, there is a need for the development of novel classes of antiviral drugs that suffer less from the emergence of resistant viruses. Antiviral drugs based on collectin-like surfactant protein D (SP-D) may fulfil these requirements. Especially porcine SP-D displays strong antiviral activity to influenza A viruses. In the present study the antiviral activity of recombinant porcine SP-D was investigated in ex vivo cultures of respiratory tract tissue infected with human influenza A virus of the H3N2 subtype. Porcine SP-D has antiviral activity in these test systems. It is suggested that porcine SP-D may be used as a venue to develop a novel class of antiviral drugs.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
antiviral activity, influenza A virus, porcine surfactant protein D
PMID:
24389095
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24389095