tetano
Editor, Senior Moderator
Virus Res. 2013 Jan 17. pii: S0168-1702(13)00005-1. doi: 10.1016/j.virusres.2013.01.004. [Epub ahead of print]
Recombinant equine herpes virus 1 (EHV-1) vaccine protects pigs against challenge with influenza A(H1N1)pmd09.
Said A, Lange E, Beer M, Damiani A, Osterrieder N.
Source
Institut f?r Virologie, Freie Universit?t Berlin, Philippstra?e 13, 10115 Berlin, Germany.
Abstract
Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a threat to human health. The pandemic influenza A(H1N1)pdm09 virus likely originated in swine through reassortment between a North American triple reassortant and Eurasian avian-like SIV. The North American triple reassortant virus has genes from avian, human and swine influenza viruses. An effective vaccine may protect the pork industry from economic losses and curb the development of new virus variants that may threaten public health. In the present study, we evaluated the efficacy of a recombinant equine herpesvirus type 1 (EHV-1) vaccine (rH_H1) expressing the hemagglutinin H1 of A(H1N1)pdm09 in the natural host. Our data shows that the engineered rH_H1 vaccine induces influenza virus-specific antibody responses in pigs and is able to protect at least partially against challenge infection: no clinical signs of disease were detected and virus replication was reduced as evidenced by decreased nasal virus shedding and faster virus clearance. Taken together, our results indicate that recombinant EHV-1 encoding H1 of A(H1N1)pdm09 may be a promising alternative for protection of pigs against infection with A(H1N1)pdm09 or other influenza viruses.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23333290
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23333290
Recombinant equine herpes virus 1 (EHV-1) vaccine protects pigs against challenge with influenza A(H1N1)pmd09.
Said A, Lange E, Beer M, Damiani A, Osterrieder N.
Source
Institut f?r Virologie, Freie Universit?t Berlin, Philippstra?e 13, 10115 Berlin, Germany.
Abstract
Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a threat to human health. The pandemic influenza A(H1N1)pdm09 virus likely originated in swine through reassortment between a North American triple reassortant and Eurasian avian-like SIV. The North American triple reassortant virus has genes from avian, human and swine influenza viruses. An effective vaccine may protect the pork industry from economic losses and curb the development of new virus variants that may threaten public health. In the present study, we evaluated the efficacy of a recombinant equine herpesvirus type 1 (EHV-1) vaccine (rH_H1) expressing the hemagglutinin H1 of A(H1N1)pdm09 in the natural host. Our data shows that the engineered rH_H1 vaccine induces influenza virus-specific antibody responses in pigs and is able to protect at least partially against challenge infection: no clinical signs of disease were detected and virus replication was reduced as evidenced by decreased nasal virus shedding and faster virus clearance. Taken together, our results indicate that recombinant EHV-1 encoding H1 of A(H1N1)pdm09 may be a promising alternative for protection of pigs against infection with A(H1N1)pdm09 or other influenza viruses.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23333290
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23333290