tetano
Editor, Senior Moderator
Curr Top Microbiol Immunol. 2014 Jul 31. [Epub ahead of print]
Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range.
Xiong X1, McCauley JW, Steinhauer DA.
Author information
Abstract
Host cell attachment by influenza A viruses is mediated by the hemagglutininHemagglutinin glycoprotein (HA), and the recognition of specific types of sialic acidSialic acid -containing glycan receptors constitutes one of the major determinants of viral host range and transmission properties. Structural studies have elucidated some of the viral determinants involved in receptor recognition of avian-like and human-like receptorsReceptors for various subtypes of influenza A viruses, and these provide clues relating to the mechanisms by which viruses evolve to adapt to human hosts. We discuss structural aspects of receptor binding by influenza HA, as well as the biological implications of functional interplay involving HA binding, NA sialidaseSialidase functions, the effects of antigenic drift, and the inhibitory properties of natural glycans present on mucosal surfaces.
PMID:
25078920
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25078920
Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range.
Xiong X1, McCauley JW, Steinhauer DA.
Author information
Abstract
Host cell attachment by influenza A viruses is mediated by the hemagglutininHemagglutinin glycoprotein (HA), and the recognition of specific types of sialic acidSialic acid -containing glycan receptors constitutes one of the major determinants of viral host range and transmission properties. Structural studies have elucidated some of the viral determinants involved in receptor recognition of avian-like and human-like receptorsReceptors for various subtypes of influenza A viruses, and these provide clues relating to the mechanisms by which viruses evolve to adapt to human hosts. We discuss structural aspects of receptor binding by influenza HA, as well as the biological implications of functional interplay involving HA binding, NA sialidaseSialidase functions, the effects of antigenic drift, and the inhibitory properties of natural glycans present on mucosal surfaces.
PMID:
25078920
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25078920