tetano
Editor, Senior Moderator
J Virol. 2014 Jul 2. pii: JVI.01077-14. [Epub ahead of print]
Recent H3N2 influenza virus clinical isolates rapidly acquire hemagglutinin or neuraminidase mutations when propagated for antigenic analyses.
Chambers BS1, Li Y1, Hodinka RL2, Hensley SE3.
Author information
Abstract
Prior to serological testing, influenza viruses are typically propagated in eggs or cell culture. Recent human H3N2 strains bind to cells with low avidity. Here, we isolated 9 primary H3N2 viral isolates from respiratory secretions of children. Upon propagation in vitro, 5 of these isolates acquired hemagglutinin or neuraminidase mutations that increased virus binding to cell surfaces. These mutations can potentially confound serological assays commonly used to identify antigenically novel influenza viruses.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID:
24991002
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24991002
Recent H3N2 influenza virus clinical isolates rapidly acquire hemagglutinin or neuraminidase mutations when propagated for antigenic analyses.
Chambers BS1, Li Y1, Hodinka RL2, Hensley SE3.
Author information
Abstract
Prior to serological testing, influenza viruses are typically propagated in eggs or cell culture. Recent human H3N2 strains bind to cells with low avidity. Here, we isolated 9 primary H3N2 viral isolates from respiratory secretions of children. Upon propagation in vitro, 5 of these isolates acquired hemagglutinin or neuraminidase mutations that increased virus binding to cell surfaces. These mutations can potentially confound serological assays commonly used to identify antigenically novel influenza viruses.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID:
24991002
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24991002