tetano
Editor, Senior Moderator
Biochem Soc Trans. 2016 Jun 15;44(3):932-6. doi: 10.1042/BST20160002.
[h=1]Recent discoveries of influenza A drug target sites to combat virus replication.[/h] Patel H[SUP]1[/SUP], Kukol A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies.
? 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
[h=4]KEYWORDS:[/h] antiviral discovery; influenza A; inhibitors; resistance; viral proteins
PMID: 27284062 [PubMed - in process]
[h=1]Recent discoveries of influenza A drug target sites to combat virus replication.[/h] Patel H[SUP]1[/SUP], Kukol A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies.
? 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
[h=4]KEYWORDS:[/h] antiviral discovery; influenza A; inhibitors; resistance; viral proteins
PMID: 27284062 [PubMed - in process]