tetano
Editor, Senior Moderator
Emerg Infect Dis. 2019 Mar;25(3):465-472. doi: 10.3201/eid2503.180167.
[h=1]Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016.[/h] Karo-Karo D, Bodewes R, Wibawa H 1st, Artika M, Pribadi ES, Diyantoro D, Pratomo W, Sugama A, Hendrayani N, Indasari I, Wibowo MH, Muljono DH, Stegeman JA, Koch G.
[h=3]Abstract[/h] Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.
[h=4]KEYWORDS:[/h] HPAI; Indonesia; West Java; highly pathogenic avian influenza; influenza; phylogenetic analysis; reassortment; respiratory infections; viruses
PMID: 30789142 DOI: 10.3201/eid2503.180167
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[h=1]Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016.[/h] Karo-Karo D, Bodewes R, Wibawa H 1st, Artika M, Pribadi ES, Diyantoro D, Pratomo W, Sugama A, Hendrayani N, Indasari I, Wibowo MH, Muljono DH, Stegeman JA, Koch G.
[h=3]Abstract[/h] Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.
[h=4]KEYWORDS:[/h] HPAI; Indonesia; West Java; highly pathogenic avian influenza; influenza; phylogenetic analysis; reassortment; respiratory infections; viruses
PMID: 30789142 DOI: 10.3201/eid2503.180167
Free full text