tetano
Editor, Senior Moderator
DOI: 10.3201/eid1611.100361
Suggested citation for this article: Bhoumik P, Hughes AL. Reassortment of ancient
neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus. Emerg Infect Dis.
2010 Nov; [Epub ahead of print]
Reassortment of Ancient Neuraminidase
and Recent Hemagglutinin in Pandemic
(H1N1) 2009 Virus
Sequence analyses show that the outbreak of pandemic (H1N1) 2009 resulted from the spread of a recently derived hemagglutinin through a population of ancient and more diverse neuraminidase
segments. This pattern implies reassortment and suggests that the novel form of hemagglutinin conferred a selective advantage.
Influenza virus A is a single-strand, negative-sense RNA virus whose genome consists of 8 RNA segments that encode 10 proteins (1). Influenza A is endemic in wild waterfowl, from which new strains periodically emerge to infect mammals, including humans and domestic pigs
(2). Strains of influenza A viruses are categorized according to serotypes for hemagglutinin (HA) and neuraminidase (NA) proteins. These proteins cover the surface of the virus, are the main targets of the host?s cellular immune response, and play major roles in the infection process
(1,3,4). In 2009, a novel strain of influenza A virus, pandemic (H1N1) 2009 virus, appeared in the human population, infecting thousands and causing many deaths (2,5?8). Phylogenetic
analyses support a close relationship between the new strain and the strains that infect swine (6?
9). Because different segments of the pandemic (H1N1) 2009 virus genome show different patterns of relationship to previously identified clades of influenza A virus sequences, these
Page 1 of 7 analyses support a role for intersegment reassortment in the origin of the new strain (6?9). For example, HA of pandemic (H1N1) 2009 virus shows a close relationship to that of classical
swine influenza A virus, and NA shows a close relationship to that of Eurasian swine influenza
A virus (6?9).
...
http://www.cdc.gov/eid/content/16/11/pdfs/10-0361.pdf
Suggested citation for this article: Bhoumik P, Hughes AL. Reassortment of ancient
neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus. Emerg Infect Dis.
2010 Nov; [Epub ahead of print]
Reassortment of Ancient Neuraminidase
and Recent Hemagglutinin in Pandemic
(H1N1) 2009 Virus
Sequence analyses show that the outbreak of pandemic (H1N1) 2009 resulted from the spread of a recently derived hemagglutinin through a population of ancient and more diverse neuraminidase
segments. This pattern implies reassortment and suggests that the novel form of hemagglutinin conferred a selective advantage.
Influenza virus A is a single-strand, negative-sense RNA virus whose genome consists of 8 RNA segments that encode 10 proteins (1). Influenza A is endemic in wild waterfowl, from which new strains periodically emerge to infect mammals, including humans and domestic pigs
(2). Strains of influenza A viruses are categorized according to serotypes for hemagglutinin (HA) and neuraminidase (NA) proteins. These proteins cover the surface of the virus, are the main targets of the host?s cellular immune response, and play major roles in the infection process
(1,3,4). In 2009, a novel strain of influenza A virus, pandemic (H1N1) 2009 virus, appeared in the human population, infecting thousands and causing many deaths (2,5?8). Phylogenetic
analyses support a close relationship between the new strain and the strains that infect swine (6?
9). Because different segments of the pandemic (H1N1) 2009 virus genome show different patterns of relationship to previously identified clades of influenza A virus sequences, these
Page 1 of 7 analyses support a role for intersegment reassortment in the origin of the new strain (6?9). For example, HA of pandemic (H1N1) 2009 virus shows a close relationship to that of classical
swine influenza A virus, and NA shows a close relationship to that of Eurasian swine influenza
A virus (6?9).
...
http://www.cdc.gov/eid/content/16/11/pdfs/10-0361.pdf