tetano
Editor, Senior Moderator
J. Virol. doi:10.1128/JVI.05262-11
Copyright ? 2011,American Society for Microbiology and/or the Listed
Authors/Institutions. All Rights Reserved.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Lam, T. T.-Y.
Right arrow Articles by Guan, Y.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lam, T. T.-Y.
Right arrow Articles by Guan, Y.
Previous Article | Next Article
Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic
Tommy Tsan-Yuk Lam1,2, Huachen Zhu1,2, Jia Wang1, David K. Smith1,2, Edward C. Holmes3,4, Robert G. Webster5, Richard Webby5, Joseph M. Peiris2, and Yi Guan1,2,*
1 International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
2 State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
3 Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania StateUniversity, Mueller Laboratory, University Park, PA 16802, USA
4 Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
5 Division of Virology, Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
* Corresponding author: Yi Guan State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong,21 Sassoon Road, Pokfulam, Hong Kong SAR, China. Tel: 85228199830; Fax: 852 28551241; Email: yguan@hku.hk
arrow
ABSTRACT
That pigs may play a pivotal role in the emergence of pandemic influenza was indicated by the recent H1N1/2009 human pandemic, likely being caused by a reassortant between viruses of the American triple-reassortant (TR) and Eurasian avian-like (EA) swine influenza lineages. As China has the largest human and pig populations in the world and is the only place where both TR and EA viruses have been reported to co-circulate, China is potentially the source of the H1N1/2009 pandemic virus. To examine this, genome sequences of 405 swine influenza viruses from China were analysed. Thirty-six TR and EA reassortant viruses were identified before and after the occurrence of the pandemic. Several of these TR-EA reassortant viruses had genotypes with most segments having the same lineage origin as the segments of the H1N1/2009 pandemic virus. However, these viruses were generated from independent reassortment events throughout our survey period, and were not associated with the current pandemic. One TR-EA reassortant, which is least similar to the pandemic virus, has persisted since 2007, while all other variants appear to be transient. Despite frequent reassortment events between TR and EA lineage viruses in China, evidence for the genesis of the 2009 pandemic virus in pigs in this region is still absent.
http://jvi.asm.org/cgi/content/short/JVI.05262-11v1?rss=1
Copyright ? 2011,American Society for Microbiology and/or the Listed
Authors/Institutions. All Rights Reserved.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Lam, T. T.-Y.
Right arrow Articles by Guan, Y.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lam, T. T.-Y.
Right arrow Articles by Guan, Y.
Previous Article | Next Article
Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic
Tommy Tsan-Yuk Lam1,2, Huachen Zhu1,2, Jia Wang1, David K. Smith1,2, Edward C. Holmes3,4, Robert G. Webster5, Richard Webby5, Joseph M. Peiris2, and Yi Guan1,2,*
1 International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
2 State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
3 Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania StateUniversity, Mueller Laboratory, University Park, PA 16802, USA
4 Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
5 Division of Virology, Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
* Corresponding author: Yi Guan State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong,21 Sassoon Road, Pokfulam, Hong Kong SAR, China. Tel: 85228199830; Fax: 852 28551241; Email: yguan@hku.hk
arrow
ABSTRACT
That pigs may play a pivotal role in the emergence of pandemic influenza was indicated by the recent H1N1/2009 human pandemic, likely being caused by a reassortant between viruses of the American triple-reassortant (TR) and Eurasian avian-like (EA) swine influenza lineages. As China has the largest human and pig populations in the world and is the only place where both TR and EA viruses have been reported to co-circulate, China is potentially the source of the H1N1/2009 pandemic virus. To examine this, genome sequences of 405 swine influenza viruses from China were analysed. Thirty-six TR and EA reassortant viruses were identified before and after the occurrence of the pandemic. Several of these TR-EA reassortant viruses had genotypes with most segments having the same lineage origin as the segments of the H1N1/2009 pandemic virus. However, these viruses were generated from independent reassortment events throughout our survey period, and were not associated with the current pandemic. One TR-EA reassortant, which is least similar to the pandemic virus, has persisted since 2007, while all other variants appear to be transient. Despite frequent reassortment events between TR and EA lineage viruses in China, evidence for the genesis of the 2009 pandemic virus in pigs in this region is still absent.
http://jvi.asm.org/cgi/content/short/JVI.05262-11v1?rss=1