tetano
Editor, Senior Moderator
Virus Res. 2010 Dec 30. [Epub ahead of print]
Reassortment between seasonal and swine-origin H1N1 influenza viruses generates viruses with enhanced growth capability in cell culture.
Octaviani CP, Li C, Noda T, Kawaoka Y.
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Abstract
One year after the emergence of the 2009 influenza (H1N1) pandemic, most cases have been relatively mild; however, the possibility of enhanced viral growth ability by reassortment with seasonal viruses cannot be overlooked. Here, we show that reassortant viruses containing a seasonal H1 HA and swine-origin NA and M genes have enhanced virus growth over their wild-type parental viruses. The emergence of such viruses in nature could, therefore, represent a threat.
Copyright © 2010. Published by Elsevier B.V.
PMID: 21195732 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21195732
Reassortment between seasonal and swine-origin H1N1 influenza viruses generates viruses with enhanced growth capability in cell culture.
Octaviani CP, Li C, Noda T, Kawaoka Y.
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Abstract
One year after the emergence of the 2009 influenza (H1N1) pandemic, most cases have been relatively mild; however, the possibility of enhanced viral growth ability by reassortment with seasonal viruses cannot be overlooked. Here, we show that reassortant viruses containing a seasonal H1 HA and swine-origin NA and M genes have enhanced virus growth over their wild-type parental viruses. The emergence of such viruses in nature could, therefore, represent a threat.
Copyright © 2010. Published by Elsevier B.V.
PMID: 21195732 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21195732