tetano
Editor, Senior Moderator
J Gen Virol. 2012 May 23. [Epub ahead of print]
Reassortants of pandemic influenza A virus H1N1/2009 and endemic porcine HxN2 viruses emerge in swine populations in Germany.
Starick E, Lange E, Grund C, Grosse Beilage E, Dohring S, Maas A, Noe T, Beer M, Harder TC.
Source
Friedrich-Loeffler-Institut;
Abstract
The incursion of the human pandemic influenza A virus H1N1 (2009) (H1N1 pdm) into pig populations and its on-going co-circulation with endemic swine influenza viruses (SIV) has yielded distinct human-porcine reassortant virus lineages. The hemagglutinin (HA) gene of H1N1 pdm was detected in 41 influenza virus positive samples from 7 swine herds in the Northwest of Germany in 2011. Eight of these samples yielded virus which carried SIV-derived neuraminidase N2 of three different porcine lineages in a H1N1 pdm backbone. The HA sequences of these viruses clustered in two distinct groups and were distinguishable from human and other porcine H1 pdm by a unique set of eight non-synonymous mutations. In contrast to the human population where H1N1 pdm replaced seasonal H1N1, this virus seems to co-circulate and interact more intensely with endemic SIV lineages giving rise to reassortants with as yet unknown biological properties and undetermined risks for public health.
PMID:
22622326
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22622326
Reassortants of pandemic influenza A virus H1N1/2009 and endemic porcine HxN2 viruses emerge in swine populations in Germany.
Starick E, Lange E, Grund C, Grosse Beilage E, Dohring S, Maas A, Noe T, Beer M, Harder TC.
Source
Friedrich-Loeffler-Institut;
Abstract
The incursion of the human pandemic influenza A virus H1N1 (2009) (H1N1 pdm) into pig populations and its on-going co-circulation with endemic swine influenza viruses (SIV) has yielded distinct human-porcine reassortant virus lineages. The hemagglutinin (HA) gene of H1N1 pdm was detected in 41 influenza virus positive samples from 7 swine herds in the Northwest of Germany in 2011. Eight of these samples yielded virus which carried SIV-derived neuraminidase N2 of three different porcine lineages in a H1N1 pdm backbone. The HA sequences of these viruses clustered in two distinct groups and were distinguishable from human and other porcine H1 pdm by a unique set of eight non-synonymous mutations. In contrast to the human population where H1N1 pdm replaced seasonal H1N1, this virus seems to co-circulate and interact more intensely with endemic SIV lineages giving rise to reassortants with as yet unknown biological properties and undetermined risks for public health.
PMID:
22622326
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22622326