Emily
Editor, Senior Moderator
No Covid vaccination history is given, but I think Italy heavily pressured seniors with financial sanctions if they didn't get vaccinated. The symptoms of CJD started 40 days before his positive PCR, so his infection may have resulted from exposure while seeking health care.
https://link.springer.com/article/10.1007/s13760-022-02023-x#citeas
Olivo, S., Furlanis, G., Buoite Stella, A. et al. Rapidly evolving Creutzfeldt–Jakob disease in COVID-19: from early status epilepticus to fatal outcome. Acta Neurol Belg (2022). https://doi.org/10.1007/s13760-022-02023-x
Abstract
We report the case of a 70-year-old man coming to our attention for new onset refractory status epilepticus (NORSE) in a rapidly evolving CJD during SARS-CoV-2 co-infection. Our case report describes a fulminant CJD evolution associated with SARS-CoV-2 infection, which led to patient death after 15 days from admission. First EEG presented continuous diffuse spikes, sharp waves and sharp-and-slow wave complexes, pattern consistent with a non-convulsive status epilepticus (NORSE). Our case supports how CJD with SARS-CoV-2 co-infection could be characterized by an accelerated evolution, as already hypothesize for others microorganism infections, and how the diagnosis might be more challenging due to its uncommon presentations, such as NORSE.
https://link.springer.com/article/10.1007/s13760-022-02023-x#citeas
Olivo, S., Furlanis, G., Buoite Stella, A. et al. Rapidly evolving Creutzfeldt–Jakob disease in COVID-19: from early status epilepticus to fatal outcome. Acta Neurol Belg (2022). https://doi.org/10.1007/s13760-022-02023-x
Abstract
We report the case of a 70-year-old man coming to our attention for new onset refractory status epilepticus (NORSE) in a rapidly evolving CJD during SARS-CoV-2 co-infection. Our case report describes a fulminant CJD evolution associated with SARS-CoV-2 infection, which led to patient death after 15 days from admission. First EEG presented continuous diffuse spikes, sharp waves and sharp-and-slow wave complexes, pattern consistent with a non-convulsive status epilepticus (NORSE). Our case supports how CJD with SARS-CoV-2 co-infection could be characterized by an accelerated evolution, as already hypothesize for others microorganism infections, and how the diagnosis might be more challenging due to its uncommon presentations, such as NORSE.