tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2017 Jun 3. pii: S1198-743X(17)30288-4. doi: 10.1016/j.cmi.2017.05.027. [Epub ahead of print]
[h=1]Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program.[/h] Chen J[SUP]1[/SUP], Yang K[SUP]1[/SUP], Zhang M[SUP]2[/SUP], Shen C[SUP]1[/SUP], Chen J[SUP]3[/SUP], Wang G[SUP]1[/SUP], Huang S[SUP]1[/SUP], Zhang M[SUP]1[/SUP], Xiong H[SUP]4[/SUP], Chen H[SUP]5[/SUP], Chen Y[SUP]6[/SUP], Xia N[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] The cross-border transmission of infectious diseases is a worldwide public health issue. Current border screening measures are insufficiently sensitive. The study objectives were to describe the epidemiological pattern of influenza infection among incoming travellers at Xiamen International Airport during non-pandemic periods and to assess the performance of a rapid influenza diagnostic test in border screening.
[h=4]METHODS:[/h] Between May 2015 and May 2016 travellers with influenza-like-illnesses (ILIs) entering China at Xiamen International Airport were screened with a rapid test, Flu Dot-ELISA, and the collected specimens were further subjected to virus isolation and phylogenetic analysis.
[h=4]RESULTS:[/h] Of the 1,540,076 incoming travellers, 1224 ILI cases were identified; 261 tested positive in the rapid test, and 176 were confirmed to be influenza through virus culture. The sensitivity and specificity of the rapid test were demonstrated to be 96.6% (170/176) and 91.3% (957/1048), respectively, and the positive predictive and negative predictive values were 65.1% (170/261) and 99.4% (957/963), respectively. The epidemiological study indicated that H3N2 and (H1N1)pdm09 were dominant in 2015 and 2016, respectively. In 2016, an increased number of influenza B isolates and co-circulation of both Victoria and Yamagata lineage influenza B viruses were observed, and mismatches between circulating influenza A(H1N1)pdm09 and influenza B Victoria lineage strains and vaccine strains also occurred.
[h=4]CONCLUSIONS:[/h] We demonstrated the suitability and value of a high-sensitivity rapid influenza test in border screening and highlighted the importance of incoming travellers as a source of imported infectious diseases.
Copyright ? 2017. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] border screening; influenza; phylogenetic analysis; rapid test; vaccine mismatch
PMID: 28587905 DOI: 10.1016/j.cmi.2017.05.027
[h=1]Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program.[/h] Chen J[SUP]1[/SUP], Yang K[SUP]1[/SUP], Zhang M[SUP]2[/SUP], Shen C[SUP]1[/SUP], Chen J[SUP]3[/SUP], Wang G[SUP]1[/SUP], Huang S[SUP]1[/SUP], Zhang M[SUP]1[/SUP], Xiong H[SUP]4[/SUP], Chen H[SUP]5[/SUP], Chen Y[SUP]6[/SUP], Xia N[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] The cross-border transmission of infectious diseases is a worldwide public health issue. Current border screening measures are insufficiently sensitive. The study objectives were to describe the epidemiological pattern of influenza infection among incoming travellers at Xiamen International Airport during non-pandemic periods and to assess the performance of a rapid influenza diagnostic test in border screening.
[h=4]METHODS:[/h] Between May 2015 and May 2016 travellers with influenza-like-illnesses (ILIs) entering China at Xiamen International Airport were screened with a rapid test, Flu Dot-ELISA, and the collected specimens were further subjected to virus isolation and phylogenetic analysis.
[h=4]RESULTS:[/h] Of the 1,540,076 incoming travellers, 1224 ILI cases were identified; 261 tested positive in the rapid test, and 176 were confirmed to be influenza through virus culture. The sensitivity and specificity of the rapid test were demonstrated to be 96.6% (170/176) and 91.3% (957/1048), respectively, and the positive predictive and negative predictive values were 65.1% (170/261) and 99.4% (957/963), respectively. The epidemiological study indicated that H3N2 and (H1N1)pdm09 were dominant in 2015 and 2016, respectively. In 2016, an increased number of influenza B isolates and co-circulation of both Victoria and Yamagata lineage influenza B viruses were observed, and mismatches between circulating influenza A(H1N1)pdm09 and influenza B Victoria lineage strains and vaccine strains also occurred.
[h=4]CONCLUSIONS:[/h] We demonstrated the suitability and value of a high-sensitivity rapid influenza test in border screening and highlighted the importance of incoming travellers as a source of imported infectious diseases.
Copyright ? 2017. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] border screening; influenza; phylogenetic analysis; rapid test; vaccine mismatch
PMID: 28587905 DOI: 10.1016/j.cmi.2017.05.027