tetano
Editor, Senior Moderator
Virol J. 2017 Aug 22;14(1):162. doi: 10.1186/s12985-017-0827-0.
[h=1]Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection.[/h] McAuley J[SUP]1[/SUP], Deng YM[SUP]2[/SUP], Gilbertson B[SUP]3[/SUP], Mackenzie-Kludas C[SUP]3[/SUP], Barr I[SUP]2[/SUP], Brown L[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010-2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engineered H3N2 IAVs differing only in the origin of the PB1 gene segment, we found that only the virus encoding the avian-derived 1968 PB1 gene matching the human pandemic strain enhanced cellular infiltrate into the alveolar spaces of infected mice. We linked this phenomenon to expression of full-length PB1-F2 protein encompassing critical "inflammatory" residues.
[h=4]KEYWORDS:[/h] Inflammation; Influenza A virus; PB1-F2; Pandemic; Pathogenicity; Respiratory disease; Seasonal; Virulence
PMID: 28830486 DOI: 10.1186/s12985-017-0827-0
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[h=1]Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection.[/h] McAuley J[SUP]1[/SUP], Deng YM[SUP]2[/SUP], Gilbertson B[SUP]3[/SUP], Mackenzie-Kludas C[SUP]3[/SUP], Barr I[SUP]2[/SUP], Brown L[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010-2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engineered H3N2 IAVs differing only in the origin of the PB1 gene segment, we found that only the virus encoding the avian-derived 1968 PB1 gene matching the human pandemic strain enhanced cellular infiltrate into the alveolar spaces of infected mice. We linked this phenomenon to expression of full-length PB1-F2 protein encompassing critical "inflammatory" residues.
[h=4]KEYWORDS:[/h] Inflammation; Influenza A virus; PB1-F2; Pandemic; Pathogenicity; Respiratory disease; Seasonal; Virulence
PMID: 28830486 DOI: 10.1186/s12985-017-0827-0
Free full text