tetano
Editor, Senior Moderator
BMC Infect Dis. 2018 Oct 11;18(1):510. doi: 10.1186/s12879-018-3429-6.
[h=1]Rapid detection of respiratory organisms with the FilmArray respiratory panel in a large children's hospital in China.[/h] Li J[SUP]1[/SUP], Tao Y[SUP]2[/SUP], Tang M[SUP]1[/SUP], Du B[SUP]1[/SUP], Xia Y[SUP]3[/SUP], Mo X[SUP]4[/SUP], Cao Q[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Respiratory tract infections (RTIs) are the most common illness in children, and rapid diagnosis is required for the optimal management of RTIs, especially severe infections.
[h=4]METHODS:[/h] Nasopharyngeal swab or sputum specimens were collected from children aged 19 days to 15 years who were admitted to a hospital in Shanghai and diagnosed with RTIs. The specimens were tested with the FilmArray Respiratory Panel, a multiplex PCR assay that detects 16 viruses, Mycoplasma pneumoniae (M. pneumoniae), Bordetella pertussis (B. pertussis) and Chlamydophila pneumoniae (C. pneumoniae).
[h=4]RESULTS:[/h] Among the 775 children studied, 626 (80.8%, 626/775) tested positive for at least one organism, and multiple organisms were detected in 198 (25.5%). Rhinoviruses/enteroviruses (25.5%, 198/775) were detected most often, followed by respiratory syncytial virus (19.5%, 151/775), parainfluenza virus 3 (14.8%, 115/775), influenza A or B (10.9%), adenovirus (10.8%), M. pneumoniae (10.6%) and B. pertussis (6.3%). The prevalence of organisms differed by age, and most of the viruses were more common in winter. Of the 140 children suspected of having pertussis, 35.0% (49/140) tested positive for B. pertussis.
[h=4]CONCLUSIONS:[/h] FilmArray RP allows the rapid simultaneous detection of a wide number of respiratory organisms, with limited hands-on time, in Chinese pediatric patients with RTIs.
[h=4]KEYWORDS:[/h] Children; FilmArray respiratory panel; Respiratory organisms; Respiratory tract infections
PMID: 30305033 DOI: 10.1186/s12879-018-3429-6
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[h=1]Rapid detection of respiratory organisms with the FilmArray respiratory panel in a large children's hospital in China.[/h] Li J[SUP]1[/SUP], Tao Y[SUP]2[/SUP], Tang M[SUP]1[/SUP], Du B[SUP]1[/SUP], Xia Y[SUP]3[/SUP], Mo X[SUP]4[/SUP], Cao Q[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Respiratory tract infections (RTIs) are the most common illness in children, and rapid diagnosis is required for the optimal management of RTIs, especially severe infections.
[h=4]METHODS:[/h] Nasopharyngeal swab or sputum specimens were collected from children aged 19 days to 15 years who were admitted to a hospital in Shanghai and diagnosed with RTIs. The specimens were tested with the FilmArray Respiratory Panel, a multiplex PCR assay that detects 16 viruses, Mycoplasma pneumoniae (M. pneumoniae), Bordetella pertussis (B. pertussis) and Chlamydophila pneumoniae (C. pneumoniae).
[h=4]RESULTS:[/h] Among the 775 children studied, 626 (80.8%, 626/775) tested positive for at least one organism, and multiple organisms were detected in 198 (25.5%). Rhinoviruses/enteroviruses (25.5%, 198/775) were detected most often, followed by respiratory syncytial virus (19.5%, 151/775), parainfluenza virus 3 (14.8%, 115/775), influenza A or B (10.9%), adenovirus (10.8%), M. pneumoniae (10.6%) and B. pertussis (6.3%). The prevalence of organisms differed by age, and most of the viruses were more common in winter. Of the 140 children suspected of having pertussis, 35.0% (49/140) tested positive for B. pertussis.
[h=4]CONCLUSIONS:[/h] FilmArray RP allows the rapid simultaneous detection of a wide number of respiratory organisms, with limited hands-on time, in Chinese pediatric patients with RTIs.
[h=4]KEYWORDS:[/h] Children; FilmArray respiratory panel; Respiratory organisms; Respiratory tract infections
PMID: 30305033 DOI: 10.1186/s12879-018-3429-6
Free full text