tetano
Editor, Senior Moderator
R Soc Open Sci
. 2021 Nov 17;8(11):210488.
doi: 10.1098/rsos.210488. eCollection 2021 Nov.
Early intervention is the key to success in COVID-19 control
Rachelle N Binny[SUP] 1 2 [/SUP], Michael G Baker[SUP] 3 4 [/SUP], Shaun C Hendy[SUP] 5 2 [/SUP], Alex James[SUP] 6 2 [/SUP], Audrey Lustig[SUP] 1 2 [/SUP], Michael J Plank[SUP] 6 2 [/SUP], Kannan M Ridings[SUP] 5 2 [/SUP], Nicholas Steyn[SUP] 6 5 2 [/SUP]
Affiliations
Abstract
New Zealand responded to the COVID-19 pandemic with a combination of border restrictions and an Alert Level (AL) system that included strict stay-at-home orders. These interventions were successful in containing an outbreak and ultimately eliminating community transmission of COVID-19 in June 2020. The timing of interventions is crucial to their success. Delaying interventions may reduce their effectiveness and mean that they need to be maintained for a longer period. We use a stochastic branching process model of COVID-19 transmission and control to simulate the epidemic trajectory in New Zealand's March-April 2020 outbreak and the effect of its interventions. We calculate key measures, including the number of reported cases and deaths, and the probability of elimination within a specified time frame. By comparing these measures under alternative timings of interventions, we show that changing the timing of AL4 (the strictest level of restrictions) has a far greater impact than the timing of border measures. Delaying AL4 restrictions results in considerably worse outcomes. Implementing border measures alone, without AL4 restrictions, is insufficient to control the outbreak. We conclude that the early introduction of stay-at-home orders was crucial in reducing the number of cases and deaths, enabling elimination.
Keywords: COVID-19; border restrictions; coronavirus; infectious disease outbreak; non-pharmaceutical interventions; stochastic model.
. 2021 Nov 17;8(11):210488.
doi: 10.1098/rsos.210488. eCollection 2021 Nov.
Early intervention is the key to success in COVID-19 control
Rachelle N Binny[SUP] 1 2 [/SUP], Michael G Baker[SUP] 3 4 [/SUP], Shaun C Hendy[SUP] 5 2 [/SUP], Alex James[SUP] 6 2 [/SUP], Audrey Lustig[SUP] 1 2 [/SUP], Michael J Plank[SUP] 6 2 [/SUP], Kannan M Ridings[SUP] 5 2 [/SUP], Nicholas Steyn[SUP] 6 5 2 [/SUP]
Affiliations
- PMID: 34804563
- PMCID: PMC8596003
- DOI: 10.1098/rsos.210488
Abstract
New Zealand responded to the COVID-19 pandemic with a combination of border restrictions and an Alert Level (AL) system that included strict stay-at-home orders. These interventions were successful in containing an outbreak and ultimately eliminating community transmission of COVID-19 in June 2020. The timing of interventions is crucial to their success. Delaying interventions may reduce their effectiveness and mean that they need to be maintained for a longer period. We use a stochastic branching process model of COVID-19 transmission and control to simulate the epidemic trajectory in New Zealand's March-April 2020 outbreak and the effect of its interventions. We calculate key measures, including the number of reported cases and deaths, and the probability of elimination within a specified time frame. By comparing these measures under alternative timings of interventions, we show that changing the timing of AL4 (the strictest level of restrictions) has a far greater impact than the timing of border measures. Delaying AL4 restrictions results in considerably worse outcomes. Implementing border measures alone, without AL4 restrictions, is insufficient to control the outbreak. We conclude that the early introduction of stay-at-home orders was crucial in reducing the number of cases and deaths, enabling elimination.
Keywords: COVID-19; border restrictions; coronavirus; infectious disease outbreak; non-pharmaceutical interventions; stochastic model.