tetano
Editor, Senior Moderator
Cold Spring Harb Perspect Med. 2019 Dec 23. pii: a038422. doi: 10.1101/cshperspect.a038422. [Epub ahead of print] [h=1]Quantifying between-Host Transmission in Influenza Virus Infections.[/h]
Johnson KEE[SUP]1[/SUP], Ghedin E[SUP]2[/SUP].
[h=3]Author information[/h] 1 Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003, USA. 2 Center for Genomics and Systems Biology, Department of Biology, and Department of Epidemiology, College of Global Public Health, New York University, New York, New York 10003, USA.
[h=3]Abstract[/h] The error-prone replication and life cycle of influenza virus generate a diverse set of genetic variants. Transmission between hosts strictly limits both the number of virus particles and the genetic diversity of virus variants that reach a new host and establish an infection. This sharp reduction in the virus population at transmission--the transmission bottleneck--is significant to the evolution of influenza virus and to its epidemic and pandemic potential. This review describes transmission bottlenecks and their effect on the diversity and evolution of influenza virus. It also reviews the methods for calculating and predicting bottleneck sizes and highlights the host and viral determinants of influenza transmissibility.
Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 31871239 DOI: 10.1101/cshperspect.a038422
Johnson KEE[SUP]1[/SUP], Ghedin E[SUP]2[/SUP].
[h=3]Author information[/h] 1 Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003, USA. 2 Center for Genomics and Systems Biology, Department of Biology, and Department of Epidemiology, College of Global Public Health, New York University, New York, New York 10003, USA.
[h=3]Abstract[/h] The error-prone replication and life cycle of influenza virus generate a diverse set of genetic variants. Transmission between hosts strictly limits both the number of virus particles and the genetic diversity of virus variants that reach a new host and establish an infection. This sharp reduction in the virus population at transmission--the transmission bottleneck--is significant to the evolution of influenza virus and to its epidemic and pandemic potential. This review describes transmission bottlenecks and their effect on the diversity and evolution of influenza virus. It also reviews the methods for calculating and predicting bottleneck sizes and highlights the host and viral determinants of influenza transmissibility.
Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 31871239 DOI: 10.1101/cshperspect.a038422