tetano
Editor, Senior Moderator
QJM
. 2023 Oct 12:hcad236.
doi: 10.1093/qjmed/hcad236. Online ahead of print. Elevated risk of multimorbidity post COVID-19 infection: protective effect of vaccination
Francisco Tsz Tsun Lai[SUP] 1 2 3 [/SUP], Wenlong Liu[SUP] 1 [/SUP], Yuqi Hu[SUP] 1 [/SUP], Cuiling Wei[SUP] 1 [/SUP], Rachel Yui Ki Chu[SUP] 1 [/SUP], Dawn Hei Lum[SUP] 1 [/SUP], Janice Ching Nam Leung[SUP] 1 [/SUP], Franco Wing Tak Cheng[SUP] 1 [/SUP], Celine Sze Ling Chui[SUP] 3 4 5 [/SUP], Xue Li[SUP] 1 3 6 [/SUP], Eric Yuk Fai Wan[SUP] 1 2 3 [/SUP], Carlos King Ho Wong[SUP] 1 2 3 [/SUP], Ching Lung Cheung[SUP] 1 3 [/SUP], Esther Wai Yin Chan[SUP] 1 3 [/SUP], Ivan Fan Ngai Hung[SUP] 6 [/SUP], Ian Chi Kei Wong[SUP] 1 3 7 [/SUP]
Affiliations
Background: It is unclear how the coronavirus disease 2019 (Covid-19) pandemic has affected multimorbidity incidence among those with one pre-existing chronic condition, as well as how vaccination could modify this association.
Aim: To examine the association of Covid-19 infection with multimorbidity incidence among people with one pre-existing chronic condition, including those with prior vaccination.
Design: Nested case-control study.
Methods: We conducted a territory-wide nested case-control study with incidence density sampling using Hong Kong electronic health records from public healthcare facilities and mandatory Covid-19 reports. People with one listed chronic condition (based on a list of 30) who developed multimorbidity during 1st January 2020 - 15th November 2022 were selected as case participants and randomly matched with up to 10 people of the same age, sex, and with the same first chronic condition without having developed multimorbidity at that point. Conditional logistic regression was used to estimate adjusted odds ratios (aOR) of multimorbidity.
Results: In total, 127,744 case participants were matched with 1,230,636 control participants. Adjusted analysis showed that there were 28%-increased odds of multimorbidity following Covid-19 [confidence interval (CI) 22% to 36%] but only 3% (non-significant) with prior full vaccination with BNT162b2 or CoronaVac (95% CI -2% to 7%). Similar associations were observed in men, women, older people aged 65 or more, and people aged 64 or younger.
Conclusions: We found a significantly elevated risk of multimorbidity following a Covid-19 episode among people with one pre-existing chronic condition. Full vaccination significantly reduced this risk increase.
Keywords: Comorbidity; Covid-19 vaccines; SARS-CoV-2; long Covid syndrome; pharmacovigilance.
. 2023 Oct 12:hcad236.
doi: 10.1093/qjmed/hcad236. Online ahead of print. Elevated risk of multimorbidity post COVID-19 infection: protective effect of vaccination
Francisco Tsz Tsun Lai[SUP] 1 2 3 [/SUP], Wenlong Liu[SUP] 1 [/SUP], Yuqi Hu[SUP] 1 [/SUP], Cuiling Wei[SUP] 1 [/SUP], Rachel Yui Ki Chu[SUP] 1 [/SUP], Dawn Hei Lum[SUP] 1 [/SUP], Janice Ching Nam Leung[SUP] 1 [/SUP], Franco Wing Tak Cheng[SUP] 1 [/SUP], Celine Sze Ling Chui[SUP] 3 4 5 [/SUP], Xue Li[SUP] 1 3 6 [/SUP], Eric Yuk Fai Wan[SUP] 1 2 3 [/SUP], Carlos King Ho Wong[SUP] 1 2 3 [/SUP], Ching Lung Cheung[SUP] 1 3 [/SUP], Esther Wai Yin Chan[SUP] 1 3 [/SUP], Ivan Fan Ngai Hung[SUP] 6 [/SUP], Ian Chi Kei Wong[SUP] 1 3 7 [/SUP]
Affiliations
- PMID: 37824396
- DOI: 10.1093/qjmed/hcad236
Background: It is unclear how the coronavirus disease 2019 (Covid-19) pandemic has affected multimorbidity incidence among those with one pre-existing chronic condition, as well as how vaccination could modify this association.
Aim: To examine the association of Covid-19 infection with multimorbidity incidence among people with one pre-existing chronic condition, including those with prior vaccination.
Design: Nested case-control study.
Methods: We conducted a territory-wide nested case-control study with incidence density sampling using Hong Kong electronic health records from public healthcare facilities and mandatory Covid-19 reports. People with one listed chronic condition (based on a list of 30) who developed multimorbidity during 1st January 2020 - 15th November 2022 were selected as case participants and randomly matched with up to 10 people of the same age, sex, and with the same first chronic condition without having developed multimorbidity at that point. Conditional logistic regression was used to estimate adjusted odds ratios (aOR) of multimorbidity.
Results: In total, 127,744 case participants were matched with 1,230,636 control participants. Adjusted analysis showed that there were 28%-increased odds of multimorbidity following Covid-19 [confidence interval (CI) 22% to 36%] but only 3% (non-significant) with prior full vaccination with BNT162b2 or CoronaVac (95% CI -2% to 7%). Similar associations were observed in men, women, older people aged 65 or more, and people aged 64 or younger.
Conclusions: We found a significantly elevated risk of multimorbidity following a Covid-19 episode among people with one pre-existing chronic condition. Full vaccination significantly reduced this risk increase.
Keywords: Comorbidity; Covid-19 vaccines; SARS-CoV-2; long Covid syndrome; pharmacovigilance.