tetano
Editor, Senior Moderator
Antiviral Res. 2020 Mar 27:104780. doi: 10.1016/j.antiviral.2020.104780. [Epub ahead of print]
Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Jalily PH[SUP]1[/SUP], Duncan MC[SUP]2[/SUP], Fedida D[SUP]1[/SUP], Wang J[SUP]3[/SUP], Tietjen I[SUP]4[/SUP].
Author information
Abstract
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strains that these drugs are no longer recommended. Here we review the current understanding of IAV M2 structure and function, mechanisms of inhibition, the rise of drug resistance mutations, and ongoing efforts to develop new antivirals that target resistant forms of M2.
Copyright ? 2020. Published by Elsevier B.V.
KEYWORDS:
Drug discovery; Drug resistance; Electrophysiology; Influenza; M2; Viroporin
PMID:32229237PMCID:PMC7102647DOI:10.1016/j.antiviral.2020.104780
Free PMC Article
Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Jalily PH[SUP]1[/SUP], Duncan MC[SUP]2[/SUP], Fedida D[SUP]1[/SUP], Wang J[SUP]3[/SUP], Tietjen I[SUP]4[/SUP].
Author information
Abstract
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strains that these drugs are no longer recommended. Here we review the current understanding of IAV M2 structure and function, mechanisms of inhibition, the rise of drug resistance mutations, and ongoing efforts to develop new antivirals that target resistant forms of M2.
Copyright ? 2020. Published by Elsevier B.V.
KEYWORDS:
Drug discovery; Drug resistance; Electrophysiology; Influenza; M2; Viroporin
PMID:32229237PMCID:PMC7102647DOI:10.1016/j.antiviral.2020.104780
Free PMC Article