tetano
Editor, Senior Moderator
Pulm Pharmacol Ther
. 2021 Aug 10;102069.
doi: 10.1016/j.pupt.2021.102069. Online ahead of print.
Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19
Minoosh Shabani[SUP] 1 [/SUP], Mehdi Totonchi[SUP] 2 [/SUP], Omidvar Rezaeimirghaed[SUP] 3 [/SUP], Latif Gachkar[SUP] 1 [/SUP], Mohammadreza Hajiesmaeili[SUP] 4 [/SUP], Ali Khoshkar[SUP] 5 [/SUP], Mahdi Amirdosara[SUP] 4 [/SUP], Ali Saffaei[SUP] 6 [/SUP], Shervin Shokouhi[SUP] 1 [/SUP], Masoud Mardani[SUP] 1 [/SUP], Ilad Alavi Darazam[SUP] 1 [/SUP], Alireza Karami[SUP] 7 [/SUP], Milad Sharifi[SUP] 7 [/SUP], Mana Zaman[SUP] 8 [/SUP], Elham Abedheydari[SUP] 9 [/SUP], Zahra Sahraei[SUP] 10 [/SUP]
Affiliations
Abstract
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has caused significant mortality worldwide. The disease attacks the lung tissue and may lead to acute respiratory distress syndrome. An in vitro study showed that hydroxychloroquine (HCQ) has a prophylactic effect against COVID-19 due to its anti-inflammatory effects. The present study aimed to evaluate the prophylactic effect of HCQ on individuals in close contact with patients with COVID-19.
Method: In this quasi-trial study, we prescribed HCQ for 7 days to all people who had close contact with a patient with COVID-19. All contacts underwent a nasal swab in two steps, and those positive for COVID-19 were excluded from the study. After 14 days of follow-up, the clinical and laboratory manifestations of COVID-19 were evaluated.
Results: A total of 113 participants completed the study. The HCQ group comprised 51 (45.13 %) contacts, and 62 (54.86 %) contacts were allocated to the control group. According to the results of clinical examination and real-time polymerase chain reaction test, 8 (12.90%) contacts in the control group were reported to have contracted COVID-19. In the HCQ group, 7 (13.72%) contacts were confirmed to have contracted COVID-19. There was no relationship between HCQ use and age, sex, underlying disorders, and laboratory data (all p >0.05). In terms of HCQ side effects, five participants experienced gastrointestinal and cutaneous side effects that subsided on discontinuation of HCQ.
Conclusion: The current study showed that HCQ had no prophylactic effect with regard to COVID-19 prevention.
Keywords: COVID-19; close contact; coronavirus; hydroxychloroquine.
. 2021 Aug 10;102069.
doi: 10.1016/j.pupt.2021.102069. Online ahead of print.
Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19
Minoosh Shabani[SUP] 1 [/SUP], Mehdi Totonchi[SUP] 2 [/SUP], Omidvar Rezaeimirghaed[SUP] 3 [/SUP], Latif Gachkar[SUP] 1 [/SUP], Mohammadreza Hajiesmaeili[SUP] 4 [/SUP], Ali Khoshkar[SUP] 5 [/SUP], Mahdi Amirdosara[SUP] 4 [/SUP], Ali Saffaei[SUP] 6 [/SUP], Shervin Shokouhi[SUP] 1 [/SUP], Masoud Mardani[SUP] 1 [/SUP], Ilad Alavi Darazam[SUP] 1 [/SUP], Alireza Karami[SUP] 7 [/SUP], Milad Sharifi[SUP] 7 [/SUP], Mana Zaman[SUP] 8 [/SUP], Elham Abedheydari[SUP] 9 [/SUP], Zahra Sahraei[SUP] 10 [/SUP]
Affiliations
- PMID: 34389507
- DOI: 10.1016/j.pupt.2021.102069
Abstract
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has caused significant mortality worldwide. The disease attacks the lung tissue and may lead to acute respiratory distress syndrome. An in vitro study showed that hydroxychloroquine (HCQ) has a prophylactic effect against COVID-19 due to its anti-inflammatory effects. The present study aimed to evaluate the prophylactic effect of HCQ on individuals in close contact with patients with COVID-19.
Method: In this quasi-trial study, we prescribed HCQ for 7 days to all people who had close contact with a patient with COVID-19. All contacts underwent a nasal swab in two steps, and those positive for COVID-19 were excluded from the study. After 14 days of follow-up, the clinical and laboratory manifestations of COVID-19 were evaluated.
Results: A total of 113 participants completed the study. The HCQ group comprised 51 (45.13 %) contacts, and 62 (54.86 %) contacts were allocated to the control group. According to the results of clinical examination and real-time polymerase chain reaction test, 8 (12.90%) contacts in the control group were reported to have contracted COVID-19. In the HCQ group, 7 (13.72%) contacts were confirmed to have contracted COVID-19. There was no relationship between HCQ use and age, sex, underlying disorders, and laboratory data (all p >0.05). In terms of HCQ side effects, five participants experienced gastrointestinal and cutaneous side effects that subsided on discontinuation of HCQ.
Conclusion: The current study showed that HCQ had no prophylactic effect with regard to COVID-19 prevention.
Keywords: COVID-19; close contact; coronavirus; hydroxychloroquine.