Pulm Circ . Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: Potential implications for

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Pulm Circ


. 2022 Apr 8;12(2):e12068.
doi: 10.1002/pul2.12068. eCollection 2022 Apr.
Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: Potential implications for SARS-CoV-2 infection


Quezia K Toe[SUP] 1 [/SUP], Theo Issitt[SUP] 1 2 [/SUP], Abdul Mahomed[SUP] 1 [/SUP], Fatma Almaghlougth[SUP] 1 [/SUP], Ishan Bahree[SUP] 1 [/SUP], Charles Sturge[SUP] 1 [/SUP], Xueqi Hu[SUP] 1 [/SUP], Ioannis Panselinas[SUP] 1 [/SUP], Anne Burke-Gaffney[SUP] 1 [/SUP], Stephen Jc Wort[SUP] 1 [/SUP], Gregory John Quinlan[SUP] 1 [/SUP]



Affiliations

• PMID: 35514788
• PMCID: PMC9063967
• DOI: 10.1002/pul2.12068

Abstract

Vascular endothelial cell dysfunction is reported in severe coronavirus disease 2019 disease, however, controversy exists regarding levels of angiotensin-converting enzyme 2 (ACE2) expression, a coreceptor for severe acute respiratory syndrome coronavirus 2, in these cells. We report ACE2 expression and positive regulation by both interleuki-6, hepcidin, and ferroportin knock-down in pulmonary artery endothelial cells with potential implications for viral infection.

Keywords: COVID‐19; hepcidin/ferroportin axis; interleukin‐6; pulmonary artery endothelial cells.