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Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

alert

Senior Moderator
Published Date: 2014-04-27 16:35:58
Subject: PRO/AH/EDR> Hantavirus update - Americas (15): USA (VA) susp. RFI
Archive Number: 20140427.2433274

HANTAVIRUS UPDATE - AMERICAS (15): USA (VIRGINIA), SUSPECTED, REQUEST FOR INFORMATION
*************************************************************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Fri 25 Apr 2014
Source: The Roanoke Times [edited]
http://www.roanoke.com/community/th...cle_88940e78-ccaa-11e3-991c-001a4bcf6878.html


In Pulaski County, 2 people died Friday [25 Apr 2014], and 4 were hospitalized after an unidentified illness. The Virginia Department of Health issued a statement about 5 p.m. on Friday that said the illness occurred among a small group of people limited to one family of 5 and a close family friend.

Josh Tolbert, the emergency management coordinator for Pulaski County, said the illness could be [a] hantavirus [infection], which can progress to hantavirus pulmonary syndrome [HPS], which can be fatal, according to the Centers for Disease Control and Prevention website.

People become infected through contact with hantavirus-infected rodents or their urine or droppings. However, health department officials cannot confirm this and are investigating other illnesses as well.

County officials had a conference on Friday [25 Apr 2014] with the Centers for Disease Control and Prevention and the Virginia Department of Health [VDH], who are assisting with the situation. Officials are encouraging people to remain calm.

The release from VDH said there is "absolutely no indication of person-to-person transmission. At this point in the investigation, there is no indication of any public health risk. This appears to be an isolated incident with a single-source exposure," the release said. "The site of possible exposure is known and on private property. It has been secured pending further environmental investigation."

Tolbert and Pulaski County Sheriff Jim Davis said the sick family is from Snowville, and certain areas were secured and blocked off by police, including where the family lived.

Tolbert said the family had been cleaning out a long-vacated mobile home near their residence and that site had been secured by police as well. He also said the family dumped materials in a container at a nearby dump site and that container has been taken away. "These are just precautionary measures until we can find out for sure," he said. "Nothing indicates it's anything more than that they were infected by the site itself."

Tolbert said samples taken from the people who died are being tested to check for possible causes, and it should be 2-3 days before the results come back.

The public was 1st alerted to the health issue on Friday [25 Apr 2014] when Pulaski County school officials alerted parents that one of its families suffered an "isolated illness."

The health department encourages anyone experiencing flu-like symptoms to see a physician, according to the release.

In the case of hantavirus[es], the virus is spread through infected rodents or their droppings, not through other people. Symptoms are flu-like. Initially, there is a fever of 101 to 104 degrees F [38-40 C] and muscle aches, followed by headaches, coughing, nausea or vomiting, diarrhea and abdominal pain.

There is no specific treatment for the disease, although medical care can help infected individuals. According to the CDC, infection with hantavirus[es] can progress to hantavirus pulmonary syndrome, which is rare and fatal about 38 per cent of the time.

While people can contract the disease anywhere, western states have experienced the most exposure.

Since 1993, according to the CDC, there have been 639 confirmed cases of HPS in the U.S., with one case in Virginia. An Appalachian Trail hiker from Australia contracted hantavirus [infection] in Virginia in 1994. He recovered. A Virginia Tech [University] wildlife graduate student studying small mammals in a rural part of nearby West Virginia also developed HPS and died in 2004.

While [a] hantavirus [infection] is suspected, officials are looking into several other possible causes, Tolbert said.

He said since the news broke of an unexplained but isolated illness in Pulaski County, emergency services have received an increase in calls regarding people with flu-like symptoms. That is expected in a situation like this, as people's concerns rise, he said. "Because we are seeing some influenza activity in the community, people in the area may experience flu symptoms," the VDH release said. "If you are concerned you may be developing influenza, please follow up with your family physician as you normally would." However, officials say there is still no public health risk.

[Byline: Tonia Moxley, Tiffany Holland, Amy Friedenberger]

--
Communicated by:

<promed@promedmail.org>

[A cluster of 6 apparently simultaneous hantavirus infections would be unusual. This report does not indicate whether these cases have progressed to disease similar to HPS or why infections with a hantavirus are suspected, as opposed to other serious respiratory infections. It does not speculate on which of the hantaviruses might be involved in these cases.

Hantaviruses that cause hantavirus pulmonary syndrome [HPS] in the eastern and southeastern USA and their rodent hosts include: Monongahela (_Peromyscus maniculatus_), New York (_P. Leucopus_), Bayou (_Oryzomys palustris_), and Black Creek Canal (_Sigmadon hispidus_) viruses. There have been 3 cases of Monongahela hantavirus infections in Randolph County, West Virginia (see the CDC Weekly Morbidity and Mortality Report of November 2004 at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5346a3.htm). Randolph county is relatively close to Pulaski county Virginia, where the above cases occurred. ProMED would appreciate receiving results of the laboratory tests when they become available.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus suspected

http://www.therepublic.com/view/story/2978500f2b8b40f2b387580460fd91b2/VA--Isolated-Illness


4 sickened by illness in Pulaski County released from hospital, investigation continues


THE ASSOCIATED PRESS
April 28, 2014 - 6:47 am EDT

ROANOKE, Virginia — Four people sickened by an unidentified illness in Pulaski County have been released from the hospital.

The Virginia Department of Health told media outlets Sunday night that the patients were discharged from Carilion Roanoke Memorial Hospital.

Two other people died Friday from the illness. The department hasn't identified any of the victims.

An investigation of what the health department calls an "isolated illness" is continuing.

New River Health District director Dr. Molly O'Dell says no new cases have been reported. She says there's no indication that there's any public health risk.

Pulaski County emergency management coordinator Josh Tolbert has said the illness could be hantavirus.

[snip]
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus suspected

I cannot help but notice the similarity to the initial reports here from Indiana in 2009, including the cleaning operations:

http://www.flutrackers.com/forum/showthread.php?p=263995

While hantavirus was originally suspected, influenza was later confirmed. It does seem like the four surviving cases were discharged rather rapidly in the current incident.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus suspected

Here's the details. The cleaning operations this time do appear to be more substantial than in the above incident.

I wonder what the medicine is that caused such a rapid recovery. If it's hantavirus and not influenza, it's not Tamiflu. Ribavirin perhaps?

http://www.roanoke.com/news/family-...cle_371448be-cef4-11e3-bbc0-001a4bcf6878.html

Family member discusses details of deadly Pulaski County illness

Posted: Monday, April 28, 2014 12:43 pm

By Jacob Demmitt and Melissa Powell | The Roanoke Times


The Snowville mother and daughter who died Friday, became sick and passed away about two weeks after they started cleaning out a mouse-infested mobile home that they planned on giving to a needy family, according to one of their family members.

Julie Simpkins and her teenage daughter, Ginger, died after experiencing symptoms consistent with the flu, strep throat and pneumonia, said Dwayne Simpkins, Julie Simpkins? brother-in-law.




Julie Simpkins? husband, Tim, and the couple?s two younger children also became ill but were released from the hospital on Sunday. Ginger Simpkins? boyfriend was hospitalized but is now back home, Dwayne Simpkins said.

Dwayne Simpkins said on the phone Monday that the Pulaski County family is still waiting to find out what caused the illness from the federal Centers for Disease Control and Prevention.

But Dwayne Simpkins said he?s ?pretty positive? that the family contracted hantavirus because they had been working in the trailer. Dwayne Simpkins said the family had lived in the mobile home years ago while building their house. After moving into the new house, the Simpkins kept the trailer on their property, about 50 to 100 feet away from their house.

?The trailer sat there for a couple years empty,? Dwayne Simpkins said. ?They sort of ignored it and hadn?t done anything with it. I think the mice just sort of took over... Apparently one of them, or more than one of them, was carrying this virus.?

Dwayne Simpkins said that Julie and Ginger Simpkins started cleaning the trailer about a week before Tim Simpkins went in there.

They finished cleaning the mobile home on April 17, and movers came to take the trailer the next day.

Ginger Simpkins first went to Carilion New River Medical Center on Wednesday morning.

?She went unconscious when her momma was rolling her in a wheelchair into the emergency room and stopped breathing,? Dwayne Simpkins said. ?They had to resuscitate her. Her heart didn?t stop but she stopped breathing.?

Ginger Simpkins was then flown to Roanoke Memorial Hospital. Dwayne Simpkins said he drove Tim and Julie Simpkins to meet her there.

?I took Timmy and Julie to the hospital to be with Ginger,? he said. ?They didn?t think they were that sick at the time. They didn?t know it, but they were headed down the same path as their daughter.?

On Wednesday and Thursday, the family assumed that the doctors were investigating the illness as hantavirus, while they were being treated for the flu, Dwayne Simpkins said.

Ginger Simpkins died on Friday morning, and Julie Simpkins died later that day.

After their deaths, Tim Simpkins and the two younger children were treated for hantavirus, Dwayne Simpkins said.

Doctors gave Tim Simpkins a different drug about noon on Friday, Dwayne Simpkins said.

?He was starting to get better by 3 or 4 o?clock. He was a whole lot better come 10 o?clock,? he said. ?Then 3 [a.m.] Saturday, he was exceptionally better,[and by] 6 [a.m.] Saturday they disconnected him from almost everything and he was out walking around coming to see his kids...very rapid change once they gave him that medicine.?

Pulaski County?s emergency services director also said last week that the illness could be hantavirus, a disease that in the United States has caused flu-like symptoms that have sometimes been fatal.

Health department officials have emphasized that there is no evidence of person-to person transmission or of a public health risk. They also have said that people should not become unduly alarmed if they develop flu-like symptoms.

Dwayne Simpkins said his brother is now home taking care of arrangements and is expecting the CDC to confirm results today or tomorrow.

?We?re trying to recover from the loss of a wife and mother and sister and daughter,? Dwayne Simpkins said. ?That?s the hard part right now. Health wise, everybody is doing good? It?s amazing. It?s like living in a fantasy. It?s not real. You still can?t wrap your mind around it to this day. It?s going to take years.?
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

From April 25:

http://www.southwesttimes.com/2014/04/illness-claims-life-of-dms-student/

Illness claims life of DMS student

Parents of Pulaski County Public School students received a message today around 12:23 p.m. that an illness had affected a student in the area. Since the release of that message, it has been confirmed that a Dublin Middle School student has passed away due to complications from the illness.

Thomas Brewster, superintendent of Pulaski County Public Schools said in a statement similar to the initial message parents received: ?We have been in contact with the New River Health District concerning an isolated illness affecting one of our families. The direction given by the NRHD was to monitor any of our students running a fever, and send them home with the recommendation for the child to see their family physician. Again, preliminary information indicates that this illness is isolated to one family. We have not received confirmation as to the cause of their illness, but we are taking steps to assure our schools are safe.?

After the message was sent out, Brewster added that the information that was released to parents in the message was very challenging to relay because so much of the information the school board was receiving was unconfirmed. He did say, however, that after personally speaking with the family and the schools, he feels confident that the rest of the students in the area are safe.

As a precaution, anyone with severe or unusual symptoms such as headaches, neck pain, or fever is encouraged to immediately consult their family physician or visit an emergency room.

[snip]
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

http://www.roanoke.com/news/communi...cle_371448be-cef4-11e3-bbc0-001a4bcf6878.html

Community mourns deaths of Snowville mother, teen

ERICA YOON | The Roanoke Times

Posted: Monday, April 28, 2014 12:43 pm | Updated: 10:01 pm, Mon Apr 28, 2014.

By Jacob Demmitt and Melissa Powell | The Roanoke Times

SNOWVILLE ? The suspected hantavirus outbreak that hospitalized a Pulaski County family of five ? killing two ? began about two weeks after the family started cleaning out a mouse-infested mobile home that they planned to give to friends in need, according to one of their family members.

Julie Simpkins and her teenage daughter, Ginger, were the first to begin cleaning the trailer that had sat unused on their property for years. The mother and daughter died on Friday.

The rest of the family ? father Tim Simpkins and two younger children ? and Ginger?s teenage boyfriend were also hospitalized with the illness but were released after medical treatment led to a quick turnaround, said Dwayne Simpkins, Tim Simpkins? brother.

Reached by phone on Monday, Dwayne Simpkins said Tim Simpkins is now back at home, making funeral arrangements. They?re still waiting to find out what caused the illness from the federal Centers for Disease Control and Prevention, but they?re ?pretty positive? the family contracted hantavirus, he said.

[snip]
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Good find, Alert! It sounds like hantavirus is the main suspect, but I think an environmental exposure irritating to lungs could also set people up for other infections such as flu. It's sad that this tragedy happened while a family was trying to help others with housing.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

There appear to be two competing narratives of what happened:

A) All 6 people helped clean out the trailer and contracted hantavirus in the process.

B) The trailer is a red herring, and the people spread (seasonal?) flu among themselves, with possible environmental or genetic factors leading to the two deaths.

Local officials seem to have jumped on explanation A, because it seems less threatening to the community as a whole, and also because it really isn't flu season.

However, there are several problems with explanation A:

1. The surviving cases seemed to recover very quickly, at least once the right medicine was provided. Previous reports of hantavirus cases around the world show that recovery often takes weeks of intensive treatment, and that there isn't too much that can be provided other that supportive care.

2. Virginia has only confirmed TWO cases of hantavirus in the past 20 years. This incident alone would have three times that number of cases.

3. Can you really imagine all six of these people cleaning out the trailer. Two of the children involved seem to be elementary school age. I can't imagine their parents allowing them to do something so dirty or dangerous.

4. Hantavirus has an incubation period of 2-3 weeks. The cleaning operations occurred on April 17, and everyone took ill between the 23rd an 25th, perhaps too early or too close together for hantavirus.

We will see if the local media can stay on this event long enough to determine which, if either, explanation is correct.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

http://www.southwesttimes.com/2014/...nowville-illnesses-could-have-been-prevented/

Emergency management gives information on how Snowville illnesses could have been prevented

By CALVIN PYNN

calvin@southwesttimes.com



Almost a week afclaim suspected case of hantavirus claimed the lives of a mother and daughter in Snowville, the exact cause has yet to be determined pending testing and investigation from the Center for Disease Control and Prevention.

The mother, Julie Simpkins, and daughter, Ginger, died last Friday, April 25, two weeks after cleaning out a trailer that had been sitting vacant on the family?s property. The rest of the Simpkins family, including the father and two younger children, as well as Ginger?s boyfriend, were hospitalized with the illness as well.

Following their deaths, the rest of the family was released from the hospital following treatment, and their current condition is unknown. Although the illness is still being investigated with a positive suspicion for hantavirus, which is transmitted through rodent excrement, Pulaski County Emergency Services felt it was necessary to inform the public on how to prevent such incident from occurring in the future.

Pulaski County Emergency Services Coordinator Josh Tolbert spoke before the Board of Supervisors at their Tuesday night meeting, giving a presentation on the precautions that can be taken to ward off this type of illness in the future. According to Tolbert, last weekend?s incident was not a common occurrence.

?The hantavirus is something very rare to Virginia,? said Tolbert. ?If this ends up being the cause of the illnesses and deaths in Snowville, it would be extremely rare to have this effect simultaneously with the number of people that it did.?

[snip]
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

http://www.wtop.com/267/3613974/Health-officials-Flu-strep-caused-deaths-in-Va

Health officials: Flu, strep caused deaths in Va.
inShare.0Wednesday - 4/30/2014, 8:16pm ET
ROANOKE, Va. (AP) -- Health officials say the illness that killed two members of a Pulaski County family and hospitalized others was not hantavirus as previously suspected.

The Roanoke Times reports (http://bit.ly/1n46JDT) that New River Health District Director Dr. Molly O'Dell says the pair died Friday from a combination of flu and strep.

O'Dell says co-infection is very rare and can be serious. Officials have not identified any of the victims.

Pulaski County emergency management officials had previously said the illness could be hantavirus.

Hantavirus is a rodent-borne illness. Infected people usually have flu-like symptoms including fever, shortness of breath, chills and muscle and body aches.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - hantavirus or influenza suspected

Not the strain I was expecting...

http://www.roanoke.com/community/th...cle_b11e22fa-d0ad-11e3-8801-0017a43b2370.html

Rare combination of flu and strep killed members of Pulaski County family

ERICA YOON | The Roanoke Times

Posted: Wednesday, April 30, 2014 5:23 pm | Updated: 7:52 pm, Wed Apr 30, 2014.

Rare combination of flu and strep killed members of Pulaski County family By Jacob Demmitt | The Roanoke Times roanoke.com

The illness that hospitalized a Snowville family of five ? killing two ? was not hantavirus as previously suspected, according to health officials.

Instead, it was a combination of two common and treatable illnesses ? influenza B and strep A ? that together claimed the lives of Julie Simpkins and her 14-year-old daughter, Ginger Simpkins, on April 25.

Individually, neither the flu nor strep cause tremendous concern, but together they are ?extremely, extremely rare? and serious, New River Health District Director Molly O?Dell said.

[snip]
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

http://www.wdbj7.com/news/local/two...rious-illness-died-from-coinfections/25742648

[snip]

Officials say it is not too late to get a flu shot. No one who was sickened last week in Pulaski County had a flu vaccine. Doctors say the vaccine may have provided some benefit, but it's not always 100 percent effective.

A doctor from Carilion Clinic says this is the first co-infection case of Influenza B and Strep A that he has seen in 35 years. Dr. Tom Kerkering is the Chief of Infectious Diseases and gave the latest news to the family today. He says this co-infection has only been documented around ten times in all medical literature and has never been formally studied.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

I've seen a couple of articles reporting cases of influenza B in the eastern half of the U.S. so that could explain this rare and deadly co-infection. I've had a bad impression of influenza B after reading about that college student from Texas who had a co-infection of flu B and staph and died from that. (I think that was the season before last. He was on Christmas holiday in the upper Midwest when he got ill.)

I was trying to read up on influenza B complicated by strep A and saw the news from Florida that tetano had posted:

http://www.flutrackers.com/forum/showthread.php?p=533260#post533260

I don't see the strain of flu or strep reported yet, but the strep was described as a 'particularly virulent and aggressive form of strep'.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

http://www.wdbj7.com/news/local/two-who-died-in-pulaski-county-from-mysterious-illness-died-from-coinfections/25742648
POSTED: 05:27 PM EDT Apr 30, 2014 UPDATED: 10:35 PM EDT Apr 30, 2014

PULASKI CO., Va. -

Influenza B and Group A streptococcus were present in the mother and daughter who died last week from a mysterious illness in Pulaski County.

The official cause of death for Julie and Ginger Simpkins has not been determined. Health officials say co-infections are very rare, but there is no threat to the public....
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

Read the whole article:

http://www.roanoke.com/news/teen-hi...cle_b7ffcec4-d0c2-11e3-a1ff-001a4bcf6878.html

Teen hit hard by loss of Pulaski Co. woman, girlfriend to illness

Posted: Wednesday, April 30, 2014 7:54 pm

By Melissa Powell | The Roanoke Times

RADFORD ? Just three days after his own release from the hospital, Kyle Mullins said he?s still struggling to understand the sudden loss of his girlfriend.

Ginger Simpkins was also hospitalized last week with what was, at the time, considered a mystery illness. The 14-year-old Snowville girl died Friday on the couple?s seven-month milestone.

[snip]

The Simpkinses were cleaning out the mobile home that sat on their property so that Mullins, 14, and his family could have a permanent place to live, Mullins said.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

Hat-tip Shiloh. These could have been other suspected diagnoses if influenza had been ruled out. I cannot find the actual text of the official statement referenced below.

http://www.cidrap.umn.edu/news-perspective/2014/05/flu-scan-may-01-2014

Tests in suspected hantavirus cluster reveal influenza B, strep A

Virginia health officials yesterday said lab tests in the wake of unexplained deaths of a Pulaski County woman and her teenage daughter were positive for influenza B and invasive Streptococcus group A, not hantavirus or other pathogens, according to a New River Health District (NRHD) statement e-mailed to journalists.

The illness also hospitalized three other family members and a close family contact, the Roanoke Times reported yesterday. The family and local officials originally suspected hantavirus, because the mother and daughter had cleaned out a mouse-infested trailer 2 weeks before they died.

Molly O'Dell, MD, director of the NRHD, said in the statement, "This type of co-infection is exceedingly rare, and it doesn't appear to pose a threat to the community at large." She said flu and strep are common illnesses that continue to circulate in the area this season.

Tests also ruled out Legionella and tularemia, according to the NRHD statement.

Some states on the East Coast have reported a late-season spike in influenza B infections, a pattern that isn't unusual. Invasive bacterial infections involving influenza B have been reported in the medical literature. For example, a case series of 19 strep A coinfections in southern England during the 2010-11 flu season included four that involved influenza B, three of which were fatal.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

Read the whole article:

http://www.roanoke.com/news/teen-hi...cle_b7ffcec4-d0c2-11e3-a1ff-001a4bcf6878.html

Teen hit hard by loss of Pulaski Co. woman, girlfriend to illness

Posted: Wednesday, April 30, 2014 7:54 pm

By Melissa Powell | The Roanoke Times

RADFORD ? Just three days after his own release from the hospital, Kyle Mullins said he?s still struggling to understand the sudden loss of his girlfriend.

Ginger Simpkins was also hospitalized last week with what was, at the time, considered a mystery illness. The 14-year-old Snowville girl died Friday on the couple?s seven-month milestone.

[snip]

The Simpkinses were cleaning out the mobile home that sat on their property so that Mullins, 14, and his family could have a permanent place to live, Mullins said.

I read the article, Alert, and it is clear that Ginger and Julie Simpkins were very, very good people and it would have been an honor to know them. The whole family sounds very special and Kyle did a wonderful job paying tribute to them. I read in another article that the mother, Julie, was a very active volunteer leader in the Meals on Wheels organization in the area and that group was devastated by her loss.
 
Re: Pulaski County, VA: 6 cases, 2 deaths, due to undiagnosed respiratory illness - influenza B and strep A confirmed

Published Date: 2014-05-04 20:26:14
Subject: PRO/EDR> Hantavirus update - Americas (15): USA (VA) NOT
Archive Number: 20140504.2447944

HANTAVIRUS UPDATE - AMERICAS (15): USA (VIRGINIA), NOT
******************************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Thu 1 May 2014
Source: The Roanoke Times [edited]
http://www.roanoke.com/community/th...2fa-d0ad-11e3-8801-0017a43b2370.html?mode=jqm


The illness that hospitalized a Snowville family of 5, killing 2, was not hantavirus as previously suspected, according to health officials.

Instead, it was a combination of 2 common and treatable illnesses, influenza type B and streptococcus Group A, that together claimed the lives of a woman and her 14-year-old daughter on 25 Apr 2014. Individually, neither the flu nor strep cause tremendous concern, but together they are "extremely, extremely rare and serious," New River Health District Director Molly O'Dell said. During a media teleconference on Wed 30 Apr 2014, O'Dell said both the flu and strep are circulating in the region, but there doesn't seem to be any threat to the community because it is so rare to become infected with both simultaneously.

The health department has not made an official cause of death finding -- that can come only from the medical examiner's office -- but health officials on the call talked about how the combination of flu and strep could be deadly. Doctors have not identified anyone else in the area who has been co-infected, O'Dell said.

No one in the family had received a flu shot, and all 5 members tested positive for the flu and showed signs of strep. It's impossible to know where they picked it up or whether they contracted both at the same time, O'Dell said. "A lot of times, what we'll say in medicine is just because you have one thing doesn't mean you can't have another, a 2nd thing," she said. "So if someone gets influenza, it certainly makes them more vulnerable to pick up bacterial infections."

The kind of co-infection that struck the family is so rare that it hasn't been studied by scientists, and only about 10 cases have ever been reported in all the medical literature that Tom Kerkering, Carilion's chief of infectious diseases, could find. "I've been doing infectious diseases for 35 years. This is the 1st time I've seen the combination," Kerkering said during the teleconference.

The family and Pulaski County's emergency services director previously suspected the family had contracted a hantavirus [infection], a rare and sometimes fatal virus passed to humans through rodent feces and urine. The women died about 2 weeks after they began cleaning out a mouse-infested mobile home that they planned to give to the family of a boyfriend who lives in a homeless shelter.

The rest of the family, the father, 2 younger children, and the boyfriend, were also hospitalized but recovered and were released.

[Byline: Jacob Demmitt]

--
Communicated by:
Justin Anderson
<janderson152@radford.edu>

[There is apparently no evidence that hantavirus was involved here, although the story is not inconsistent with the illness spread by aerosolization of virus in dried rodent urine.

To this moderator, the co-infection of influenza and streptococci is not at all rare. A discussion of the subject is found at:
Aebi T, Weisser M, Bucher E, et al: Co-infection of influenza B and streptococci causing severe pneumonia and septic shock in healthy women. BMC Infectious Diseases 2010, 10:308 doi:10.1186/1471-2334-10-308. - Mod.LL]

[Influenza virus infection is well known to predispose to secondary bacterial pneumonias and contribute to excess mortality observed during influenza epidemics. Some influenza epidemics have been more frequently complicated by secondary bacterial pneumonias than others. The majority of deaths in the 1918-1919 influenza pandemic likely resulted directly from secondary bacterial pneumonia (D.M. Morens, J.K. Taubenberger, A.S. Fauci. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis, 198 (2008), pp. 962-970).

Similarly, during the 1957-58 [H2N2] influenza pandemic, 70-80 percent of patients who died of influenza-related complications had bacterial pneumonia (http://www.sciencedirect.com/science/article/pii/S0140673658924048); whereas, severe or fatal cases of 2009 H1N1 influenza A were found to be less frequently complicated by bacterial infection (http://www.sciencedirect.com/science/article/pii/S1201971212000367).

_Streptococcus pneumoniae_ is usually the most common secondary bacterial pathogen to complicate influenza virus infection, although _Staphylococcus aureus_, Group A streptococci (GAS), and _Haemophilus influenzae_ have also been secondary bacterial pathogens. Reports of secondary bacterial infection with community-associated methicillin-resistant _S. aureus_ strains have been increasing in recent years.

A synergistic relationship between influenza virus and bacteria has been demonstrated in animal models. For example, an otherwise nonlethal intranasal GAS infection when preceded by a nonlethal influenza A virus (IAV) infection was found to lead to lethal invasive GAS infections in 90 percent of mice (Okamoto S1, Kawabata S, Nakagawa I, et al. Influenza A virus-infected hosts boost an invasive type of _Streptococcus pyogenes_ infection in mice. J Virol. 2003 Apr;77(7):4104-12. Abstract available at: http://www.ncbi.nlm.nih.gov/pubmed/12634369).
In this case, infection of lung alveolar epithelial cells by the influenza A virus resulted in attachment of GAS to influenza virus expressed on the alveolar cell surface and internalization of GAS.

Synergism has similarly been found in a mouse model for _S. pneumoniae_ (McCullers, JA, Rehg JE. Lethal synergism between influenza virus and _Streptococcus pneumoniae_: characterization of a mouse model and the role of platelet-activating factor receptor. J Infect Dis. 2002;186:341-350. Abstract available at: http://www.readcube.com/articles/10.1086/341462?locale=en) and for _S. aureus_ (Lee M-H, Arrecubieta C, Martin FJ, et al. A postinfluenza model of _Staphylococcus aureus_ pneumonia. J Infect Dis. 2010; 201 (4): 508-515. Available at: http://jid.oxfordjournals.org/content/201/4/508.full).

The viral-bacterial interaction is likely complex and includes alterations of pulmonary physiology and host immune defenses, changes in expression of receptors to which bacteria adhere, and enhancement of the inflammatory process (McCullers JA. Insights into the Interaction between Influenza Virus and _Pneumococcus_. Clin. Microbiol. Rev. 2006; 19(3): 571-582. Available at: http://cmr.asm.org/content/19/3/571.full.) - Mod.ML
 
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