tetano
Editor, Senior Moderator
Public Health Pract (Oxf)
. 2023 Jun;5:100350.
doi: 10.1016/j.puhip.2022.100350. Epub 2022 Dec 10.
Differences in case-fatality-rate of emerging SARS-CoV-2 variants
Jing Liu[SUP] 1 [/SUP], Haozhen Wei[SUP] 1 [/SUP], Daihai He[SUP] 1 2 [/SUP]
Affiliations
Abstract
Objects: Variants of Severe-Acute-Respiratory-Syndrome Coronavirus-2 (SARS-CoV-2) has caused tremendous impact globally. It has been widely reported that the Omicron (B.1.1.529) variant is less deadly than the Delta (B.1.617.2) variant, presumably due to immunity from vaccination and previous infection. When measuring the severity of a variant, Case-Fatality-Rate (CFR) is often estimated. The purpose of this work is to calculate the change in CFR of different variants over time from a large number of countries/regions since the start of the pandemic in 2020.
Study design: A Cross-sectional study.
Methods: We extend the comparison to all previous VOCs in 58 counties/regions. We use reported death divided by reported cases in 30-day sliding window with a two-week shift between reported death and reported cases.
Results: The drop from Delta variant to Omicron variant is substantial and the difference between subvariants of Omicron is not evident.
Conclusion: We showed that the CFR dropped over time, presumably due to vaccine-induced immune and infection induced immune. Population age structure and prevalence of comorbidity influence CFR.
Keywords: CFR; COVID-19; Delta variant; Omicron variant.
. 2023 Jun;5:100350.
doi: 10.1016/j.puhip.2022.100350. Epub 2022 Dec 10.
Differences in case-fatality-rate of emerging SARS-CoV-2 variants
Jing Liu[SUP] 1 [/SUP], Haozhen Wei[SUP] 1 [/SUP], Daihai He[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36532099
- PMCID: PMC9741492
- DOI: 10.1016/j.puhip.2022.100350
Abstract
Objects: Variants of Severe-Acute-Respiratory-Syndrome Coronavirus-2 (SARS-CoV-2) has caused tremendous impact globally. It has been widely reported that the Omicron (B.1.1.529) variant is less deadly than the Delta (B.1.617.2) variant, presumably due to immunity from vaccination and previous infection. When measuring the severity of a variant, Case-Fatality-Rate (CFR) is often estimated. The purpose of this work is to calculate the change in CFR of different variants over time from a large number of countries/regions since the start of the pandemic in 2020.
Study design: A Cross-sectional study.
Methods: We extend the comparison to all previous VOCs in 58 counties/regions. We use reported death divided by reported cases in 30-day sliding window with a two-week shift between reported death and reported cases.
Results: The drop from Delta variant to Omicron variant is substantial and the difference between subvariants of Omicron is not evident.
Conclusion: We showed that the CFR dropped over time, presumably due to vaccine-induced immune and infection induced immune. Population age structure and prevalence of comorbidity influence CFR.
Keywords: CFR; COVID-19; Delta variant; Omicron variant.