tetano
Editor, Senior Moderator
Psychol Med
. 2023 Sep 5;1-11.
doi: 10.1017/S0033291723002313. Online ahead of print. Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome
Sangeetha Shyam[SUP] 1 2 3 [/SUP], Carlos Gómez-Martínez[SUP] 1 2 3 [/SUP], Indira Paz-Graniel[SUP] 1 2 3 [/SUP], José J Gaforio[SUP] 4 5 [/SUP], Miguel Ángel Martínez-González[SUP] 1 6 7 [/SUP], Dolores Corella[SUP] 1 8 [/SUP], Montserrat Fitó[SUP] 1 9 [/SUP], J Alfredo Martínez[SUP] 1 10 11 [/SUP], Ángel M Alonso-Gómez[SUP] 1 12 [/SUP], Julia Wärnberg[SUP] 1 13 [/SUP], Jesús Vioque[SUP] 4 14 [/SUP], Dora Romaguera[SUP] 1 15 [/SUP], José López-Miranda[SUP] 1 16 [/SUP], Ramon Estruch[SUP] 1 17 [/SUP], Francisco J Tinahones[SUP] 1 18 [/SUP], José Manuel Santos-Lozano[SUP] 1 19 [/SUP], J Luís Serra-Majem[SUP] 1 20 [/SUP], Aurora Bueno-Cavanillas[SUP] 4 21 [/SUP], Josep A Tur[SUP] 1 22 [/SUP], Vicente Martín Sánchez[SUP] 4 11 23 [/SUP], Xavier Pintó[SUP] 1 24 [/SUP], María Ortiz Ramos[SUP] 25 [/SUP], Josep Vidal[SUP] 26 27 [/SUP], Maria Mar Alcarria[SUP] 28 [/SUP], Lidia Daimiel[SUP] 1 29 30 [/SUP], Emilio Ros[SUP] 1 31 [/SUP], Fernando Fernandez-Aranda[SUP] 1 32 33 [/SUP], Stephanie K Nishi[SUP] 1 2 3 34 [/SUP], Oscar García Regata[SUP] 35 [/SUP], Estefania Toledo[SUP] 1 6 [/SUP], Jose V Sorli[SUP] 1 8 [/SUP], Olga Castañer[SUP] 9 [/SUP], Antonio Garcia-Rios[SUP] 1 16 [/SUP], Rafael Valls-Enguix[SUP] 36 [/SUP], Napoleon Perez-Farinos[SUP] 1 13 [/SUP], M Angeles Zulet[SUP] 1 10 [/SUP], Elena Rayó-Gago[SUP] 15 [/SUP], Rosa Casas[SUP] 1 17 [/SUP], Mario Rivera-Izquierdo[SUP] 21 [/SUP], Lucas Tojal-Sierra[SUP] 1 12 [/SUP], Miguel Damas-Fuentes[SUP] 18 [/SUP], Pilar Buil-Cosiales[SUP] 1 6 37 [/SUP], Rebeca Fernández-Carrion[SUP] 1 8 [/SUP], Albert Goday[SUP] 9 [/SUP], Patricia J Peña-Orihuela[SUP] 1 16 [/SUP], Laura Compañ-Gabucio[SUP] 4 14 [/SUP], Javier Diez-Espino[SUP] 1 6 37 [/SUP], Susanna Tello[SUP] 9 [/SUP], Ana González-Pinto[SUP] 38 [/SUP], Víctor de la O[SUP] 1 6 [/SUP], Miguel Delgado-Rodríguez[SUP] 11 39 [/SUP], Nancy Babio[SUP] 1 2 3 [/SUP], Jordi Salas-Salvadó[SUP] 1 2 3 [/SUP]
Affiliations
Background: The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID-19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort.
Methods: Participants (n = 5486) aged 55-75 years were included in this longitudinal cohort. COVID-19 status (positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology.
Results: COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15-40) weeks post-infection [fully adjusted β = 0.65 points, 95% confidence interval (CI) 0.15-1.15; p = 0.011]. This association was particularly prominent in women (β = 1.38 points, 95% CI 0.44-2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II ≥ 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13-2.30, p = 0.008).
Conclusions: COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.
Keywords: COVID-19; PREDIMED-Plus; SARS-CoV-2; depression; older adults.
. 2023 Sep 5;1-11.
doi: 10.1017/S0033291723002313. Online ahead of print. Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome
Sangeetha Shyam[SUP] 1 2 3 [/SUP], Carlos Gómez-Martínez[SUP] 1 2 3 [/SUP], Indira Paz-Graniel[SUP] 1 2 3 [/SUP], José J Gaforio[SUP] 4 5 [/SUP], Miguel Ángel Martínez-González[SUP] 1 6 7 [/SUP], Dolores Corella[SUP] 1 8 [/SUP], Montserrat Fitó[SUP] 1 9 [/SUP], J Alfredo Martínez[SUP] 1 10 11 [/SUP], Ángel M Alonso-Gómez[SUP] 1 12 [/SUP], Julia Wärnberg[SUP] 1 13 [/SUP], Jesús Vioque[SUP] 4 14 [/SUP], Dora Romaguera[SUP] 1 15 [/SUP], José López-Miranda[SUP] 1 16 [/SUP], Ramon Estruch[SUP] 1 17 [/SUP], Francisco J Tinahones[SUP] 1 18 [/SUP], José Manuel Santos-Lozano[SUP] 1 19 [/SUP], J Luís Serra-Majem[SUP] 1 20 [/SUP], Aurora Bueno-Cavanillas[SUP] 4 21 [/SUP], Josep A Tur[SUP] 1 22 [/SUP], Vicente Martín Sánchez[SUP] 4 11 23 [/SUP], Xavier Pintó[SUP] 1 24 [/SUP], María Ortiz Ramos[SUP] 25 [/SUP], Josep Vidal[SUP] 26 27 [/SUP], Maria Mar Alcarria[SUP] 28 [/SUP], Lidia Daimiel[SUP] 1 29 30 [/SUP], Emilio Ros[SUP] 1 31 [/SUP], Fernando Fernandez-Aranda[SUP] 1 32 33 [/SUP], Stephanie K Nishi[SUP] 1 2 3 34 [/SUP], Oscar García Regata[SUP] 35 [/SUP], Estefania Toledo[SUP] 1 6 [/SUP], Jose V Sorli[SUP] 1 8 [/SUP], Olga Castañer[SUP] 9 [/SUP], Antonio Garcia-Rios[SUP] 1 16 [/SUP], Rafael Valls-Enguix[SUP] 36 [/SUP], Napoleon Perez-Farinos[SUP] 1 13 [/SUP], M Angeles Zulet[SUP] 1 10 [/SUP], Elena Rayó-Gago[SUP] 15 [/SUP], Rosa Casas[SUP] 1 17 [/SUP], Mario Rivera-Izquierdo[SUP] 21 [/SUP], Lucas Tojal-Sierra[SUP] 1 12 [/SUP], Miguel Damas-Fuentes[SUP] 18 [/SUP], Pilar Buil-Cosiales[SUP] 1 6 37 [/SUP], Rebeca Fernández-Carrion[SUP] 1 8 [/SUP], Albert Goday[SUP] 9 [/SUP], Patricia J Peña-Orihuela[SUP] 1 16 [/SUP], Laura Compañ-Gabucio[SUP] 4 14 [/SUP], Javier Diez-Espino[SUP] 1 6 37 [/SUP], Susanna Tello[SUP] 9 [/SUP], Ana González-Pinto[SUP] 38 [/SUP], Víctor de la O[SUP] 1 6 [/SUP], Miguel Delgado-Rodríguez[SUP] 11 39 [/SUP], Nancy Babio[SUP] 1 2 3 [/SUP], Jordi Salas-Salvadó[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37667630
- DOI: 10.1017/S0033291723002313
Background: The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID-19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort.
Methods: Participants (n = 5486) aged 55-75 years were included in this longitudinal cohort. COVID-19 status (positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology.
Results: COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15-40) weeks post-infection [fully adjusted β = 0.65 points, 95% confidence interval (CI) 0.15-1.15; p = 0.011]. This association was particularly prominent in women (β = 1.38 points, 95% CI 0.44-2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II ≥ 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13-2.30, p = 0.008).
Conclusions: COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.
Keywords: COVID-19; PREDIMED-Plus; SARS-CoV-2; depression; older adults.