Proton channel activity of influenza A virus matrix protein 2 contributes to autophagy arrest

[tetano]

J Virol. 2015 Oct 14. pii: JVI.00576-15. [Epub ahead of print]
[h=1]Proton channel activity of influenza A virus matrix protein 2 contributes to autophagy arrest.[/h] Ren Y[SUP]1[/SUP], Li C[SUP]2[/SUP], Feng L[SUP]3[/SUP], Pan W[SUP]4[/SUP], Li L[SUP]4[/SUP], Wang Q[SUP]3[/SUP], Li J[SUP]4[/SUP], Li N[SUP]4[/SUP], Han L[SUP]4[/SUP], Zheng X[SUP]4[/SUP], Niu X[SUP]4[/SUP], Sun C[SUP]3[/SUP], Chen L[SUP]5[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] Influenza A virus infection can arrest autophagy as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2). Thus, M2 proton channel activity plays a role in blocking the fusion of autophagosome with lysosome, which might be a key mechanism for arresting autophagy.
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PMID: 26468520 [PubMed - as supplied by publisher]