tetano
Editor, Senior Moderator
J Infect Dis. 2012 Sep 4. [Epub ahead of print]
Protein Energy Malnutrition Decreases Immunity and Increases Susceptibility to Influenza Infection in Mice.
Taylor AK, Cao W, Vora KP, Cruz JD, Shieh WJ, Zaki SR, Katz JM, Sambhara S, Gangappa S.
Source
Influenza Division, National Center for Immunization and Respiratory Diseases.
Abstract
Background. Protein energy malnutrition (PEM), a common cause of secondary immune deficiency in children, is associated with an increased risk of infections. Very few studies have addressed the relevance of PEM as a risk factor for influenza.Methods. We investigated the influence of PEM on susceptibility to, and immune responses following, influenza virus infection using isocaloric diets providing either adequate protein (AP; 18%) or very low protein (VLP; 2%) in a mouse model.Results. We found that mice maintained on the VLP diet, when compared to mice fed with AP diet, exhibited more severe disease following influenza infection based on virus persistence, trafficking of inflammatory cell types to the lung tissue, and virus-induced mortality. Furthermore, groups of mice maintained on the VLP diet showed significantly lower virus-specific antibody response and a reduction in influenza nuclear protein-specific CD8(+) T cells compared with mice fed on the AP diet. Importantly, switching diets for the group maintained on the VLP, to AP, improved virus clearance, as well as protective immunity to viral challenge.Conclusions. Our results highlight the impact of protein energy on immunity to influenza infection and suggest balanced protein energy replenishment may be one strategy to boost immunity against influenza viral infections.
PMID:
22949306
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22949306
Protein Energy Malnutrition Decreases Immunity and Increases Susceptibility to Influenza Infection in Mice.
Taylor AK, Cao W, Vora KP, Cruz JD, Shieh WJ, Zaki SR, Katz JM, Sambhara S, Gangappa S.
Source
Influenza Division, National Center for Immunization and Respiratory Diseases.
Abstract
Background. Protein energy malnutrition (PEM), a common cause of secondary immune deficiency in children, is associated with an increased risk of infections. Very few studies have addressed the relevance of PEM as a risk factor for influenza.Methods. We investigated the influence of PEM on susceptibility to, and immune responses following, influenza virus infection using isocaloric diets providing either adequate protein (AP; 18%) or very low protein (VLP; 2%) in a mouse model.Results. We found that mice maintained on the VLP diet, when compared to mice fed with AP diet, exhibited more severe disease following influenza infection based on virus persistence, trafficking of inflammatory cell types to the lung tissue, and virus-induced mortality. Furthermore, groups of mice maintained on the VLP diet showed significantly lower virus-specific antibody response and a reduction in influenza nuclear protein-specific CD8(+) T cells compared with mice fed on the AP diet. Importantly, switching diets for the group maintained on the VLP, to AP, improved virus clearance, as well as protective immunity to viral challenge.Conclusions. Our results highlight the impact of protein energy on immunity to influenza infection and suggest balanced protein energy replenishment may be one strategy to boost immunity against influenza viral infections.
PMID:
22949306
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22949306