tetano
Editor, Senior Moderator
Nat Immunol. 2016 Oct 31. doi: 10.1038/ni.3563. [Epub ahead of print]
[h=1]Protective neutralizing influenza antibody response in the absence of T follicular helper cells.[/h] Miyauchi K[SUP]1[/SUP], Sugimoto-Ishige A[SUP]2[/SUP], Harada Y[SUP]3[/SUP], Adachi Y[SUP]4[/SUP], Usami Y[SUP]1[/SUP], Kaji T[SUP]2,[/SUP][SUP]5[/SUP], Inoue K[SUP]6[/SUP], Hasegawa H[SUP]7[/SUP], Watanabe T[SUP]8[/SUP], Hijikata A[SUP]9[/SUP], Fukuyama S[SUP]10,[/SUP][SUP]11[/SUP], Maemura T[SUP]10[/SUP], Okada-Hatakeyama M[SUP]6[/SUP], Ohara O[SUP]8[/SUP], Kawaoka Y[SUP]10,[/SUP][SUP]11,[/SUP][SUP]12[/SUP], Takahashi Y[SUP]4[/SUP], Takemori T[SUP]2[/SUP], Kubo M[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Virus infection induces the development of T follicular helper (T[SUB]FH[/SUB]) and T helper 1 (T[SUB]H[/SUB]1) cells. Although T[SUB]FH[/SUB] cells are important in anti-viral humoral immunity, the contribution of T[SUB]H[/SUB]1 cells to a protective antibody response remains unknown. We found that IgG2 antibodies predominated in the response to vaccination with inactivated influenza A virus (IAV) and were responsible for protective immunity to lethal challenge with pathogenic H5N1 and pandemic H1N1 IAV strains, even in mice that lacked T[SUB]FH[/SUB] cells and germinal centers. The cytokines interleukin-21 and interferon-γ, which are secreted from T[SUB]H[/SUB]1 cells, were essential for the observed greater persistence and higher titers of IgG2 protective antibodies. Our results suggest that T[SUB]H[/SUB]1 induction could be a promising strategy for producing effective neutralizing antibodies against emerging influenza viruses.
PMID: 27798619 DOI: 10.1038/ni.3563
[PubMed - as supplied by publisher]
[h=1]Protective neutralizing influenza antibody response in the absence of T follicular helper cells.[/h] Miyauchi K[SUP]1[/SUP], Sugimoto-Ishige A[SUP]2[/SUP], Harada Y[SUP]3[/SUP], Adachi Y[SUP]4[/SUP], Usami Y[SUP]1[/SUP], Kaji T[SUP]2,[/SUP][SUP]5[/SUP], Inoue K[SUP]6[/SUP], Hasegawa H[SUP]7[/SUP], Watanabe T[SUP]8[/SUP], Hijikata A[SUP]9[/SUP], Fukuyama S[SUP]10,[/SUP][SUP]11[/SUP], Maemura T[SUP]10[/SUP], Okada-Hatakeyama M[SUP]6[/SUP], Ohara O[SUP]8[/SUP], Kawaoka Y[SUP]10,[/SUP][SUP]11,[/SUP][SUP]12[/SUP], Takahashi Y[SUP]4[/SUP], Takemori T[SUP]2[/SUP], Kubo M[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Virus infection induces the development of T follicular helper (T[SUB]FH[/SUB]) and T helper 1 (T[SUB]H[/SUB]1) cells. Although T[SUB]FH[/SUB] cells are important in anti-viral humoral immunity, the contribution of T[SUB]H[/SUB]1 cells to a protective antibody response remains unknown. We found that IgG2 antibodies predominated in the response to vaccination with inactivated influenza A virus (IAV) and were responsible for protective immunity to lethal challenge with pathogenic H5N1 and pandemic H1N1 IAV strains, even in mice that lacked T[SUB]FH[/SUB] cells and germinal centers. The cytokines interleukin-21 and interferon-γ, which are secreted from T[SUB]H[/SUB]1 cells, were essential for the observed greater persistence and higher titers of IgG2 protective antibodies. Our results suggest that T[SUB]H[/SUB]1 induction could be a promising strategy for producing effective neutralizing antibodies against emerging influenza viruses.
PMID: 27798619 DOI: 10.1038/ni.3563
[PubMed - as supplied by publisher]