tetano
Editor, Senior Moderator
BMC Vet Res. 2015 Apr 2;11(1):85. doi: 10.1186/s12917-015-0399-4.
[h=1]Protective immunity against influenza H5N1 virus challenge in chickens by oral administration of recombinant Lactococcus lactis expressing neuraminidase.[/h] Lei H[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Peng X[SUP]4[/SUP], Ouyang J[SUP]5[/SUP], Zhao D[SUP]6[/SUP], Jiao H[SUP]7[/SUP], Shu H[SUP]8[/SUP], Ge X[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Highly pathogenic H5N1 avian influenza viruses pose a debilitating pandemic threat in poultry. Current influenza vaccines predominantly focus on hemagglutinin (HA) which anti-HA antibodies are often neutralizing, and are used routinely to assess vaccine immunogenicity. However, Neuraminidase (NA), the other major glycoprotein on the surface of the influenza virus, has historically served as the target for antiviral drug therapy and is much less studied in the context of humoral immunity. The aim of this study was to evaluate the protective immunity of NA based on Lactococcus lactis (L.lactis) expression system against homologous H5N1 virus challenge in a chicken model.
[h=4]RESULTS:[/h]
[h=1]Protective immunity against influenza H5N1 virus challenge in chickens by oral administration of recombinant Lactococcus lactis expressing neuraminidase.[/h] Lei H[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Peng X[SUP]4[/SUP], Ouyang J[SUP]5[/SUP], Zhao D[SUP]6[/SUP], Jiao H[SUP]7[/SUP], Shu H[SUP]8[/SUP], Ge X[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Highly pathogenic H5N1 avian influenza viruses pose a debilitating pandemic threat in poultry. Current influenza vaccines predominantly focus on hemagglutinin (HA) which anti-HA antibodies are often neutralizing, and are used routinely to assess vaccine immunogenicity. However, Neuraminidase (NA), the other major glycoprotein on the surface of the influenza virus, has historically served as the target for antiviral drug therapy and is much less studied in the context of humoral immunity. The aim of this study was to evaluate the protective immunity of NA based on Lactococcus lactis (L.lactis) expression system against homologous H5N1 virus challenge in a chicken model.
[h=4]RESULTS:[/h]