tetano
Editor, Senior Moderator
PLoS One. 2012;7(3):e33678. Epub 2012 Mar 19.
Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection.
Yoo DG, Kim MC, Park MK, Park KM, Quan FS, Song JM, Wee JJ, Wang BZ, Cho YK, Compans RW, Kang SM.
Source
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Abstract
Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection.
PMID:
22442708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22442708
Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection.
Yoo DG, Kim MC, Park MK, Park KM, Quan FS, Song JM, Wee JJ, Wang BZ, Cho YK, Compans RW, Kang SM.
Source
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Abstract
Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection.
PMID:
22442708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22442708