tetano
Editor, Senior Moderator
Mol Med Rep. 2014 Mar 27. doi: 10.3892/mmr.2014.2076. [Epub ahead of print]
Protective effect of fluvastatin on influenza virus infection.
Peng J1, Zhang D1, Ma Y1, Wang G2, Guo Z3, Lu J1.
Author information
Abstract
Statins are 3‑hydroxy‑3‑methylglutaryl coenzyme A reductase inhibitors and have pleiotropic effects. It has been suggested that statins may be a potential treatment during the next influenza pandemic. In a previous study we found that a statin/caffeine combination protects BALB/c mice against Influenza A, subtypes haemagglutinin type 5 and neuraminidase type 1 (H5N1), H3N2 and H1N1 infection. The effect of statins alone on influenza virus infection, however, is not known. In this study, it was investigated whether fluvastatin is capable of inhibiting influenza A virus replication in vitro. The results demonstrated that the synthesis of viral RNA and protein was affected by fluvastatin treatment. Virus production was markedly reduced when fluvastatin was administered simultaneously with the virus; however, a greater inhibition was observed when fluvastatin was added following viral adsorption. The selectivity index [SI; 50% cytotoxic concentration (CC50)/50% inhibition concentration (IC50)], however, was only 21. It was further demonstrated that fluvastatin protects host cells against influenza‑induced inflammation by reducing the production of tumour necrosis factor‑α, interleukin 8 and interferon γ. In conclusion, the results demonstrated that fluvastatin exerted a minor inhibitory effect on influenza virus infection, which involved anti‑inflammatory activities.
PMID:
24676773
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24676773
Protective effect of fluvastatin on influenza virus infection.
Peng J1, Zhang D1, Ma Y1, Wang G2, Guo Z3, Lu J1.
Author information
Abstract
Statins are 3‑hydroxy‑3‑methylglutaryl coenzyme A reductase inhibitors and have pleiotropic effects. It has been suggested that statins may be a potential treatment during the next influenza pandemic. In a previous study we found that a statin/caffeine combination protects BALB/c mice against Influenza A, subtypes haemagglutinin type 5 and neuraminidase type 1 (H5N1), H3N2 and H1N1 infection. The effect of statins alone on influenza virus infection, however, is not known. In this study, it was investigated whether fluvastatin is capable of inhibiting influenza A virus replication in vitro. The results demonstrated that the synthesis of viral RNA and protein was affected by fluvastatin treatment. Virus production was markedly reduced when fluvastatin was administered simultaneously with the virus; however, a greater inhibition was observed when fluvastatin was added following viral adsorption. The selectivity index [SI; 50% cytotoxic concentration (CC50)/50% inhibition concentration (IC50)], however, was only 21. It was further demonstrated that fluvastatin protects host cells against influenza‑induced inflammation by reducing the production of tumour necrosis factor‑α, interleukin 8 and interferon γ. In conclusion, the results demonstrated that fluvastatin exerted a minor inhibitory effect on influenza virus infection, which involved anti‑inflammatory activities.
PMID:
24676773
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24676773