tetano
Editor, Senior Moderator
Virology. 2014 Mar;452-453:152-7. doi: 10.1016/j.virol.2014.01.003. Epub 2014 Jan 31.
Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy.
Teijaro JR1, Walsh KB2, Long JP3, Tordoff KP4, Stark GV5, Eisfeld AJ6, Kawaoka Y7, Rosen H8, Oldstone MB9.
Author information
Abstract
Influenza infection of humans remains an important public health problem. Vaccine strategies result in a significant but only partial control (65-85%) of infection. Thus, chemotherapeutic approaches are needed to provide a solution both for vaccine failures and to limit infection in the unvaccinated population. Previously (Walsh et al., 2011; Teijaro et al., 2011) documented that sphingosine-1-phosphate 1 receptor (S1P1R) agonists significantly protected mice against pathogenic H1N1 influenza virus by limiting immunopathologic damage while allowing host control of the infection. Here we extend that observation by documenting S1P1R agonist can control pathogenic H1N1 influenza infection in ferrets. S1P1R agonist was more effective in reducing pulmonary injury than the antiviral drug oseltamivir but, importantly, combined therapy was significantly more effective than either therapy alone.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Ferrets, H1N1 influenza, Oseltamivir, Pathogenesis, RP-002, S1P1 Rec agonist
PMID:
24606692
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24606692
Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy.
Teijaro JR1, Walsh KB2, Long JP3, Tordoff KP4, Stark GV5, Eisfeld AJ6, Kawaoka Y7, Rosen H8, Oldstone MB9.
Author information
Abstract
Influenza infection of humans remains an important public health problem. Vaccine strategies result in a significant but only partial control (65-85%) of infection. Thus, chemotherapeutic approaches are needed to provide a solution both for vaccine failures and to limit infection in the unvaccinated population. Previously (Walsh et al., 2011; Teijaro et al., 2011) documented that sphingosine-1-phosphate 1 receptor (S1P1R) agonists significantly protected mice against pathogenic H1N1 influenza virus by limiting immunopathologic damage while allowing host control of the infection. Here we extend that observation by documenting S1P1R agonist can control pathogenic H1N1 influenza infection in ferrets. S1P1R agonist was more effective in reducing pulmonary injury than the antiviral drug oseltamivir but, importantly, combined therapy was significantly more effective than either therapy alone.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Ferrets, H1N1 influenza, Oseltamivir, Pathogenesis, RP-002, S1P1 Rec agonist
PMID:
24606692
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24606692