tetano
Editor, Senior Moderator
Arch Virol. 2013 Jun 15. [Epub ahead of print]
Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination.
Sarkadi J, Jankovics M, Kis Z, Skare J, Fodor K, Gonczol E, Visontai I, Vajo Z, Jankovics I.
Source
Division of Virology, National Center for Epidemiology, Budapest, 1097, Hungary.
Abstract
Chinese painted quails immunized with a single dose (6 μg HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD50 of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral antigens or RNA were detected in cloacal swabs from immunized animals. Sera obtained post-immunization gave low titres in serological assays against the vaccine and the challenge viruses. Our results demonstrate the protective efficacy of the NIBRG-14 strain against the challenge virus and the usefulness of these small birds in protection studies of influenza vaccines.
PMID:
23771736
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23771736
Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination.
Sarkadi J, Jankovics M, Kis Z, Skare J, Fodor K, Gonczol E, Visontai I, Vajo Z, Jankovics I.
Source
Division of Virology, National Center for Epidemiology, Budapest, 1097, Hungary.
Abstract
Chinese painted quails immunized with a single dose (6 μg HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD50 of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral antigens or RNA were detected in cloacal swabs from immunized animals. Sera obtained post-immunization gave low titres in serological assays against the vaccine and the challenge viruses. Our results demonstrate the protective efficacy of the NIBRG-14 strain against the challenge virus and the usefulness of these small birds in protection studies of influenza vaccines.
PMID:
23771736
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23771736