Pathfinder
Editor, Senior Moderator
Obstetrics & Gynecology:
Post Author Corrections: July 29, 2016
doi: 10.1097/AOG.0000000000001625
Original Research: PDF Only
Prolonged Detection of Zika Virus RNA in Pregnant Women.
Meaney-Delman, Dana MD, MPH; Oduyebo, Titilope MD, MPH; Polen, Kara N.D. MPH; White, Jennifer L. MPH; Bingham, Andrea M. PhD; Slavinski, Sally A. DVM, MPH; Heberlein-Larson, Lea MPH; St. George, Kirsten MAppSc, PhD; Rakeman, Jennifer L. PhD; Hills, Susan MBBS; Olson, Christine K. MD; Adamski, Alys PhD; Culver Barlow, Lauren MS; Lee, Ellen H. MD; Likos, Anna M. MD, MPH; Mu?oz, Jorge L. PhD; Petersen, Emily E. MD; Dufort, Elizabeth M. MD; Dean, Amy B. PhD; Cortese, Margaret M. MD; Santiago, Gilberto A. PhD; Bhatnagar, Julu PhD; Powers, Ann M. PhD; Zaki, Sherif MD, PhD; Petersen, Lyle R. MD, MPH; Jamieson, Denise J. MD; Honein, Margaret A. PhD; for the U.S. Zika Pregnancy Registry Prolonged Viremia Working Group
Published Ahead-of-Print
Collapse BoxAbstract
OBJECTIVE: Zika virus infection during pregnancy is a cause of microcephaly and other fetal brain abnormalities. Reports indicate that the duration of detectable viral RNA in serum after symptom onset is brief. In a recent case report involving a severely affected fetus, Zika virus RNA was detected in maternal serum 10 weeks after symptom onset, longer than the duration of RNA detection in serum previously reported. This report summarizes the clinical and laboratory characteristics of pregnant women with prolonged detection of Zika virus RNA in serum that were reported to the U.S. Zika Pregnancy Registry.
...
RESULTS: Prolonged Zika virus RNA detection in serum was identified in four symptomatic pregnant women up to 46 days after symptom onset and in one asymptomatic pregnant woman 53 days postexposure. Among the five pregnancies, one pregnancy had evidence of fetal Zika virus infection confirmed by histopathologic examination of fetal tissue, three pregnancies resulted in live births of apparently healthy neonates with no reported abnormalities, and one pregnancy is ongoing.
CONCLUSION: Zika virus RNA was detected in the serum of five pregnant women beyond the previously estimated timeframe. Additional real-time RT-PCR testing of pregnant women might provide more data about prolonged detection of Zika virus RNA and the possible diagnostic, epidemiologic, and clinical implications for pregnant women.
(C) 2016 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.
http://journals.lww.com/greenjourna...tion_of_Zika_Virus_RNA_in_Pregnant.98675.aspx
Post Author Corrections: July 29, 2016
doi: 10.1097/AOG.0000000000001625
Original Research: PDF Only
Prolonged Detection of Zika Virus RNA in Pregnant Women.
Meaney-Delman, Dana MD, MPH; Oduyebo, Titilope MD, MPH; Polen, Kara N.D. MPH; White, Jennifer L. MPH; Bingham, Andrea M. PhD; Slavinski, Sally A. DVM, MPH; Heberlein-Larson, Lea MPH; St. George, Kirsten MAppSc, PhD; Rakeman, Jennifer L. PhD; Hills, Susan MBBS; Olson, Christine K. MD; Adamski, Alys PhD; Culver Barlow, Lauren MS; Lee, Ellen H. MD; Likos, Anna M. MD, MPH; Mu?oz, Jorge L. PhD; Petersen, Emily E. MD; Dufort, Elizabeth M. MD; Dean, Amy B. PhD; Cortese, Margaret M. MD; Santiago, Gilberto A. PhD; Bhatnagar, Julu PhD; Powers, Ann M. PhD; Zaki, Sherif MD, PhD; Petersen, Lyle R. MD, MPH; Jamieson, Denise J. MD; Honein, Margaret A. PhD; for the U.S. Zika Pregnancy Registry Prolonged Viremia Working Group
Published Ahead-of-Print
Collapse BoxAbstract
OBJECTIVE: Zika virus infection during pregnancy is a cause of microcephaly and other fetal brain abnormalities. Reports indicate that the duration of detectable viral RNA in serum after symptom onset is brief. In a recent case report involving a severely affected fetus, Zika virus RNA was detected in maternal serum 10 weeks after symptom onset, longer than the duration of RNA detection in serum previously reported. This report summarizes the clinical and laboratory characteristics of pregnant women with prolonged detection of Zika virus RNA in serum that were reported to the U.S. Zika Pregnancy Registry.
...
RESULTS: Prolonged Zika virus RNA detection in serum was identified in four symptomatic pregnant women up to 46 days after symptom onset and in one asymptomatic pregnant woman 53 days postexposure. Among the five pregnancies, one pregnancy had evidence of fetal Zika virus infection confirmed by histopathologic examination of fetal tissue, three pregnancies resulted in live births of apparently healthy neonates with no reported abnormalities, and one pregnancy is ongoing.
CONCLUSION: Zika virus RNA was detected in the serum of five pregnant women beyond the previously estimated timeframe. Additional real-time RT-PCR testing of pregnant women might provide more data about prolonged detection of Zika virus RNA and the possible diagnostic, epidemiologic, and clinical implications for pregnant women.
(C) 2016 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.
http://journals.lww.com/greenjourna...tion_of_Zika_Virus_RNA_in_Pregnant.98675.aspx