tetano
Editor, Senior Moderator
Thorax. 2018 Sep 18. pii: thoraxjnl-2018-211916. doi: 10.1136/thoraxjnl-2018-211916. [Epub ahead of print]
[h=1]Progranulin aggravates pulmonary immunopathology during influenza virus infection.[/h] Luo Q[SUP]1,[/SUP][SUP]2[/SUP], Yan X[SUP]1[/SUP], Tu H[SUP]1[/SUP], Yin Y[SUP]2[/SUP], Cao J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Progranulin (PGRN) exerts multiple functions in various inflammatory diseases. However, the role of PGRN in the pathogenesis of virus infection is unknown. Here, we demonstrated that PGRN production was up-regulated in clinical and experimental influenza, which contributed to the deleterious inflammatory response after influenza virus infection in mice. PGRN-deficient mice were protected from influenza virus-induced lung injury and mortality. Decreased mortality was associated with significantly reduced influx of neutrophils and monocytes/macrophages, release of cytokines and chemokines, and permeability of the alveolar-epithelial barrier without affecting viral clearance. Our findings suggest that PGRN exacerbates pulmonary immunopathology during influenza virus infection.
[h=4]KEYWORDS:[/h] infection control; pneumonia; viral infection
PMID: 30228207 DOI: 10.1136/thoraxjnl-2018-211916
[h=1]Progranulin aggravates pulmonary immunopathology during influenza virus infection.[/h] Luo Q[SUP]1,[/SUP][SUP]2[/SUP], Yan X[SUP]1[/SUP], Tu H[SUP]1[/SUP], Yin Y[SUP]2[/SUP], Cao J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Progranulin (PGRN) exerts multiple functions in various inflammatory diseases. However, the role of PGRN in the pathogenesis of virus infection is unknown. Here, we demonstrated that PGRN production was up-regulated in clinical and experimental influenza, which contributed to the deleterious inflammatory response after influenza virus infection in mice. PGRN-deficient mice were protected from influenza virus-induced lung injury and mortality. Decreased mortality was associated with significantly reduced influx of neutrophils and monocytes/macrophages, release of cytokines and chemokines, and permeability of the alveolar-epithelial barrier without affecting viral clearance. Our findings suggest that PGRN exacerbates pulmonary immunopathology during influenza virus infection.
[h=4]KEYWORDS:[/h] infection control; pneumonia; viral infection
PMID: 30228207 DOI: 10.1136/thoraxjnl-2018-211916