tetano
Editor, Senior Moderator
Cardiology. 2019 Sep 12:1-7. doi: 10.1159/000501230. [Epub ahead of print]
[h=1]Prognostic Implications of Influenza Virus Infection in a Cardiac Intensive Care Unit: Potential Impact of a Screening Program.[/h] Mu?oz P[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Vicent L[SUP]5[/SUP], Bouza E[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Sousa-Casasnovas I[SUP]5[/SUP], L?pez-Roa P[SUP]1[/SUP], Ju?rez M[SUP]5[/SUP], Eworo A[SUP]1[/SUP], Devesa C[SUP]5[/SUP], Bru?a V[SUP]5[/SUP], Catal?n P[SUP]1[/SUP], Fern?ndez-Avil?s F[SUP]5[/SUP], Mart?nez-Sell?s M[SUP]6,[/SUP][SUP]7,[/SUP][SUP]8[/SUP].
[h=3]Author information[/h] 1 Servicio de Microbiolog?a Cl?nica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Mara??n, Madrid, Spain. 2 Instituto de Investigaci?n Sanitaria Hospital Gregorio Mara??n, Madrid, Spain. 3 Departamento de Medicina. Universidad Complutense, Madrid, Spain. 4 CIBER Enfermedades Respiratorias, CIBERES (CB06/06/0058), Madrid, Spain. 5 Servicio de Cardiolog?a, Hospital General Universitario Gregorio Mara??n, CIBERCV, Madrid, Spain. 6 Departamento de Medicina. Universidad Complutense, Madrid, Spain, mmselles@secardiologia.es. 7 Servicio de Cardiolog?a, Hospital General Universitario Gregorio Mara??n, CIBERCV, Madrid, Spain, mmselles@secardiologia.es. 8 Universidad Europea, Madrid, Spain, mmselles@secardiologia.es.
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Our goal was to determine the presentation and prognosis of influenza in an intensive cardiac care unit and to analyze the impact of an active surveillance program in the diagnosis.
[h=4]METHODS:[/h] We performed a prospective registry during the flu season in a coronary unit. In the first phase, no systematic screening was performed. Systematic influenza A and B detection was performed in a second phase for all patients admitted.
[h=4]RESULTS:[/h] From 227 patients, we identified 17 (7.5%) with influenza. Influenza patients were more likely to have a non-ischemic cause of admission (14 patients [82.4%] vs. 48 patients [40.3%], p = 0.002), fever (8 patients [47.1%] vs. 3 patients [2.6%], p < 0.001), and respiratory failure (7 patients [41.2%] vs. 8 patients [7%], p = 0.001). Influenza infection was an independent predictor of mortality (odds ratio 12.0, 95% confidence interval 1.9-13.6, p < 0.001). The incidence of influenza was 6.6% (6 patients) when no active screening was performed and 7.9% (11 patients) when systematic detection was performed (p = 0.005). The time to diagnosis was shorter in the systematic screening phase (0.92 ? 1.6 vs. 5.2 ? 3.8 days, p = 0.01).
[h=4]CONCLUSIONS:[/h] Influenza affects approximately 8% of patients admitted to an intensive cardiac care unit during the flu season, with a high mortality rate. An active surveillance program improves early detection.
? 2019 S. Karger AG, Basel.
[h=4]KEYWORDS:[/h] Cardiac intensive care unit; Influenza; Screening
PMID: 31514195 DOI: 10.1159/000501230
[h=1]Prognostic Implications of Influenza Virus Infection in a Cardiac Intensive Care Unit: Potential Impact of a Screening Program.[/h] Mu?oz P[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Vicent L[SUP]5[/SUP], Bouza E[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Sousa-Casasnovas I[SUP]5[/SUP], L?pez-Roa P[SUP]1[/SUP], Ju?rez M[SUP]5[/SUP], Eworo A[SUP]1[/SUP], Devesa C[SUP]5[/SUP], Bru?a V[SUP]5[/SUP], Catal?n P[SUP]1[/SUP], Fern?ndez-Avil?s F[SUP]5[/SUP], Mart?nez-Sell?s M[SUP]6,[/SUP][SUP]7,[/SUP][SUP]8[/SUP].
[h=3]Author information[/h] 1 Servicio de Microbiolog?a Cl?nica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Mara??n, Madrid, Spain. 2 Instituto de Investigaci?n Sanitaria Hospital Gregorio Mara??n, Madrid, Spain. 3 Departamento de Medicina. Universidad Complutense, Madrid, Spain. 4 CIBER Enfermedades Respiratorias, CIBERES (CB06/06/0058), Madrid, Spain. 5 Servicio de Cardiolog?a, Hospital General Universitario Gregorio Mara??n, CIBERCV, Madrid, Spain. 6 Departamento de Medicina. Universidad Complutense, Madrid, Spain, mmselles@secardiologia.es. 7 Servicio de Cardiolog?a, Hospital General Universitario Gregorio Mara??n, CIBERCV, Madrid, Spain, mmselles@secardiologia.es. 8 Universidad Europea, Madrid, Spain, mmselles@secardiologia.es.
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Our goal was to determine the presentation and prognosis of influenza in an intensive cardiac care unit and to analyze the impact of an active surveillance program in the diagnosis.
[h=4]METHODS:[/h] We performed a prospective registry during the flu season in a coronary unit. In the first phase, no systematic screening was performed. Systematic influenza A and B detection was performed in a second phase for all patients admitted.
[h=4]RESULTS:[/h] From 227 patients, we identified 17 (7.5%) with influenza. Influenza patients were more likely to have a non-ischemic cause of admission (14 patients [82.4%] vs. 48 patients [40.3%], p = 0.002), fever (8 patients [47.1%] vs. 3 patients [2.6%], p < 0.001), and respiratory failure (7 patients [41.2%] vs. 8 patients [7%], p = 0.001). Influenza infection was an independent predictor of mortality (odds ratio 12.0, 95% confidence interval 1.9-13.6, p < 0.001). The incidence of influenza was 6.6% (6 patients) when no active screening was performed and 7.9% (11 patients) when systematic detection was performed (p = 0.005). The time to diagnosis was shorter in the systematic screening phase (0.92 ? 1.6 vs. 5.2 ? 3.8 days, p = 0.01).
[h=4]CONCLUSIONS:[/h] Influenza affects approximately 8% of patients admitted to an intensive cardiac care unit during the flu season, with a high mortality rate. An active surveillance program improves early detection.
? 2019 S. Karger AG, Basel.
[h=4]KEYWORDS:[/h] Cardiac intensive care unit; Influenza; Screening
PMID: 31514195 DOI: 10.1159/000501230