tetano
Editor, Senior Moderator
Antivir Ther. 2011 Dec 16. doi: 10.3851/IMP2019. [Epub ahead of print]
Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy.
Pa?o-Pardo JR, Rodr?guez-Ba?o J, Mart?nez-S?nchez N, Viasus D, Fari?as MC, Leyes M, L?pez-Medrano F, Pach?n J, Torre-Cisneros J, Oteo JA, Pumarola T, Garc?a-Gasalla M, Ortega L, Segura F, Carratal? J; the Novel Influenza A(H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI).
Source
Hospital Universitario La Paz - IDIPAZ, Madrid, Spain.
Abstract
BACKGROUND:
Initial reports suggested that novel A(H1N1) influenza virus (2009 A[H1N1]v) infection was significantly more severe in pregnant than in non-pregnant women. In Spain, antiviral therapy was recommended for pregnant women from the beginning of the 2009 pandemic.
METHODS:
The prospective cohort study included consecutive pregnant and non-pregnant women of reproductive age with a proven diagnosis of 2009 A(H1N1)v admitted to any of the 13 participating Spanish hospitals between 12 June and 10 November 2009.
RESULTS:
In total, 98 pregnant and 112 non-pregnant women with proven 2009 A(H1N1)v hospitalized during the study period were included. Influenza was more severe among non-pregnant patients than pregnant patients with respect to outcomes of both intensive care unit admission (18% versus 2%; P<0.001) and death (5 versus 0; P=0.06). Pregnant women had fewer associated comorbid conditions other than pregnancy (18% versus 44%; P<0.001); they were also admitted earlier than non-pregnant women (median days since onset of symptoms: 2 versus 3; P<0.001) and a higher percentage received early antiviral therapy (41% versus 28%; P=0.03). Neither a multivariate nor a matched cohort analysis found pregnancy to be associated with greater severity than that associated with hospitalized, seriously ill non-pregnant women.
CONCLUSIONS:
2009 A(H1N1)v influenza was not associated with worse outcomes in hospitalized pregnant women compared with non-pregnant ones of reproductive age in a context of early diagnosis and antiviral therapy.
PMID:
22301005
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22301005
Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy.
Pa?o-Pardo JR, Rodr?guez-Ba?o J, Mart?nez-S?nchez N, Viasus D, Fari?as MC, Leyes M, L?pez-Medrano F, Pach?n J, Torre-Cisneros J, Oteo JA, Pumarola T, Garc?a-Gasalla M, Ortega L, Segura F, Carratal? J; the Novel Influenza A(H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI).
Source
Hospital Universitario La Paz - IDIPAZ, Madrid, Spain.
Abstract
BACKGROUND:
Initial reports suggested that novel A(H1N1) influenza virus (2009 A[H1N1]v) infection was significantly more severe in pregnant than in non-pregnant women. In Spain, antiviral therapy was recommended for pregnant women from the beginning of the 2009 pandemic.
METHODS:
The prospective cohort study included consecutive pregnant and non-pregnant women of reproductive age with a proven diagnosis of 2009 A(H1N1)v admitted to any of the 13 participating Spanish hospitals between 12 June and 10 November 2009.
RESULTS:
In total, 98 pregnant and 112 non-pregnant women with proven 2009 A(H1N1)v hospitalized during the study period were included. Influenza was more severe among non-pregnant patients than pregnant patients with respect to outcomes of both intensive care unit admission (18% versus 2%; P<0.001) and death (5 versus 0; P=0.06). Pregnant women had fewer associated comorbid conditions other than pregnancy (18% versus 44%; P<0.001); they were also admitted earlier than non-pregnant women (median days since onset of symptoms: 2 versus 3; P<0.001) and a higher percentage received early antiviral therapy (41% versus 28%; P=0.03). Neither a multivariate nor a matched cohort analysis found pregnancy to be associated with greater severity than that associated with hospitalized, seriously ill non-pregnant women.
CONCLUSIONS:
2009 A(H1N1)v influenza was not associated with worse outcomes in hospitalized pregnant women compared with non-pregnant ones of reproductive age in a context of early diagnosis and antiviral therapy.
PMID:
22301005
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22301005