tetano
Editor, Senior Moderator
Prog Urol
. 2020 May 22;S1166-7087(20)30186-X.
doi: 10.1016/j.purol.2020.05.007. Online ahead of print.
COVID-19 and the Male Susceptibility: The Role of ACE2, TMPRSS2 and the Androgen Receptor
G Mjaess[SUP] 1 [/SUP], A Karam[SUP] 2 [/SUP], F Aoun[SUP] 3 [/SUP], S Albisinni[SUP] 4 [/SUP], T Roumegu?re[SUP] 5 [/SUP]
Affiliations
Abstract
COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy.
Keywords: Angiotensin-Converting Enzyme 2; COVID-19; Enzyme de conversion de l’angiotensine 2; R?cepteur aux androg?nes; S?rine prot?ase transmembranaire 2; Type II Transmembrane Serine Protease; androgen receptor.
. 2020 May 22;S1166-7087(20)30186-X.
doi: 10.1016/j.purol.2020.05.007. Online ahead of print.
COVID-19 and the Male Susceptibility: The Role of ACE2, TMPRSS2 and the Androgen Receptor
G Mjaess[SUP] 1 [/SUP], A Karam[SUP] 2 [/SUP], F Aoun[SUP] 3 [/SUP], S Albisinni[SUP] 4 [/SUP], T Roumegu?re[SUP] 5 [/SUP]
Affiliations
- PMID: 32620366
- DOI: 10.1016/j.purol.2020.05.007
Abstract
COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy.
Keywords: Angiotensin-Converting Enzyme 2; COVID-19; Enzyme de conversion de l’angiotensine 2; R?cepteur aux androg?nes; S?rine prot?ase transmembranaire 2; Type II Transmembrane Serine Protease; androgen receptor.