Giuseppe
Emeritus
Proc Natl Acad Sci U S A. 2009 Mar 13. [Epub ahead of print]
Sympathetic nervous system control of anti-influenza CD8+ T cell responses.
Grebe KM, Hickman HD, Irvine KR, Takeda K, Bennink JR, Yewdell JW. - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic.
Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8(+) T cell responses to viral and cellular antigens presented by direct priming or cross-priming.
The sympathetic nervous system also suppresses antiviral CD4(+) T cell responses, but this is not required for suppressing CD8(+) T cell responses.
Adoptive transfer experiments indicate that enhanced CD8(+) responses do not result from permanent alterations in CD8(+) T cell function in sympathectomized mice.
Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate na?ve CD8(+) T cells.
We also show that antiviral CD8(+) T cell responses are enhanced by administration of a beta(2) (but not beta(1) or alpha) adrenergic antagonist.
These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8(+) T cell responses and indicate that CD8(+) T cell responses may be altered in patients using beta-blockers, one of the most widely prescribed classes of drugs.
PMID: 19286971 [PubMed - as supplied by publisher]
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Sympathetic nervous system control of anti-influenza CD8+ T cell responses.
Grebe KM, Hickman HD, Irvine KR, Takeda K, Bennink JR, Yewdell JW. - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic.
Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8(+) T cell responses to viral and cellular antigens presented by direct priming or cross-priming.
The sympathetic nervous system also suppresses antiviral CD4(+) T cell responses, but this is not required for suppressing CD8(+) T cell responses.
Adoptive transfer experiments indicate that enhanced CD8(+) responses do not result from permanent alterations in CD8(+) T cell function in sympathectomized mice.
Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate na?ve CD8(+) T cells.
We also show that antiviral CD8(+) T cell responses are enhanced by administration of a beta(2) (but not beta(1) or alpha) adrenergic antagonist.
These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8(+) T cell responses and indicate that CD8(+) T cell responses may be altered in patients using beta-blockers, one of the most widely prescribed classes of drugs.
PMID: 19286971 [PubMed - as supplied by publisher]
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