Giuseppe
Emeritus
IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection (Proc Natl Acad Sci USA, abstract, edited)
IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
1. David G. Brooks a,1, 2. Kevin B. Walsh b, 3. Heidi Elsaesser a, and 4. Michael B. A. Oldstone b,1
Author Affiliations
1. aDepartment of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095; and
2. bViral-Immunobiology Laboratory, Department of Immunology and Microbial Science and Department of Infectology, The Scripps Research Institute, La Jolla, CA 92037
1. Contributed by Michael B. A. Oldstone, December 16, 2009 (sent for review September 17, 2009)
Abstract
Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector and memory T cell response. In response to lymphocytic choriomeningitis virus (LCMV) infection, the immunosuppressive cytokine IL-10 is rapidly up-regulated; however, how IL-10 is regulating what is often considered an ?optimal? immune response is unclear. We demonstrate that IL-10 directly inhibits effector and memory CD4 T cell responses following an acutely resolved viral infection. Blockade of IL-10 enhanced the magnitude and the functional capacity of effector CD4 T cells that translated into increased and more effective memory responses. On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination.
* T cell memory/ T cell programming
* vaccination
Footnotes
* 1To whom correspondence may be addressed. E-mail: dbrooks@em.ucla.edu or mbaobo@scripps.edu.
* Author contributions: D.G.B. and M.B.A.O. designed research; D.G.B., K.B.W., and H.E. performed research; D.G.B., K.B.W., and M.B.A.O. analyzed data; and D.G.B. and M.B.A.O. wrote the paper.
* The authors declare no conflict of interest.
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<cite cite="http://www.pnas.org/content/107/7/3018.short?rss=1">IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection ? PNAS</cite>1. David G. Brooks a,1, 2. Kevin B. Walsh b, 3. Heidi Elsaesser a, and 4. Michael B. A. Oldstone b,1
Author Affiliations
1. aDepartment of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095; and
2. bViral-Immunobiology Laboratory, Department of Immunology and Microbial Science and Department of Infectology, The Scripps Research Institute, La Jolla, CA 92037
1. Contributed by Michael B. A. Oldstone, December 16, 2009 (sent for review September 17, 2009)
Abstract
Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector and memory T cell response. In response to lymphocytic choriomeningitis virus (LCMV) infection, the immunosuppressive cytokine IL-10 is rapidly up-regulated; however, how IL-10 is regulating what is often considered an ?optimal? immune response is unclear. We demonstrate that IL-10 directly inhibits effector and memory CD4 T cell responses following an acutely resolved viral infection. Blockade of IL-10 enhanced the magnitude and the functional capacity of effector CD4 T cells that translated into increased and more effective memory responses. On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination.
* T cell memory/ T cell programming
* vaccination
Footnotes
* 1To whom correspondence may be addressed. E-mail: dbrooks@em.ucla.edu or mbaobo@scripps.edu.
* Author contributions: D.G.B. and M.B.A.O. designed research; D.G.B., K.B.W., and H.E. performed research; D.G.B., K.B.W., and M.B.A.O. analyzed data; and D.G.B. and M.B.A.O. wrote the paper.
* The authors declare no conflict of interest.
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