tetano
Editor, Senior Moderator
Proc Natl Acad Sci U S A
. 2020 May 21;201915681.
doi: 10.1073/pnas.1915681117. Online ahead of print.
T [SUB]RM[/SUB] Integrins CD103 and CD49a Differentially Support Adherence and Motility After Resolution of Influenza Virus Infection
Emma C Reilly[SUP] 1 [/SUP], Kris Lambert Emo[SUP] 1 [/SUP], Patrick M Buckley[SUP] 1 [/SUP], Nicholas S Reilly[SUP] 2 [/SUP], Ian Smith[SUP] 1 [/SUP], Francisco A Chaves[SUP] 1 [/SUP], Hongmei Yang[SUP] 3 [/SUP], Patrick W Oakes[SUP] 2 4 [/SUP], David J Topham[SUP] 5 6 [/SUP]
Affiliations
Abstract
Tissue-resident memory CD8 T (T[SUB]RM[/SUB]) cells are a unique immune memory subset that develops and remains in peripheral tissues at the site of infection, providing future host resistance upon reexposure to that pathogen. In the pulmonary system, T[SUB]RM[/SUB] are identified through S1P antagonist CD69 and expression of integrins CD103/β7 and CD49a/CD29(β1). Contrary to the established role of CD69 on CD8 T cells, the functions of CD103 and CD49a on this population are not well defined. This study examines the expression patterns and functions of CD103 and CD49a with a specific focus on their impact on T cell motility during influenza virus infection. We show that the T[SUB]RM[/SUB] cell surface phenotype develops by 2 wk postinfection, with the majority of the population expressing CD49a and a subset that is also positive for CD103. Despite a previously established role in retaining T[SUB]RM[/SUB] in peripheral tissues, CD49a facilitates locomotion of virus-specific CD8 T cells, both in vitro and in vivo. These results demonstrate that CD49a may contribute to local surveillance mechanisms of the T[SUB]RM[/SUB] population.
Keywords: T cell; influenza; integrin; memory.
Copyright ? 2020 the Author(s). Published by PNAS.
. 2020 May 21;201915681.
doi: 10.1073/pnas.1915681117. Online ahead of print.
T [SUB]RM[/SUB] Integrins CD103 and CD49a Differentially Support Adherence and Motility After Resolution of Influenza Virus Infection
Emma C Reilly[SUP] 1 [/SUP], Kris Lambert Emo[SUP] 1 [/SUP], Patrick M Buckley[SUP] 1 [/SUP], Nicholas S Reilly[SUP] 2 [/SUP], Ian Smith[SUP] 1 [/SUP], Francisco A Chaves[SUP] 1 [/SUP], Hongmei Yang[SUP] 3 [/SUP], Patrick W Oakes[SUP] 2 4 [/SUP], David J Topham[SUP] 5 6 [/SUP]
Affiliations
- PMID: 32439709
- DOI: 10.1073/pnas.1915681117
Abstract
Tissue-resident memory CD8 T (T[SUB]RM[/SUB]) cells are a unique immune memory subset that develops and remains in peripheral tissues at the site of infection, providing future host resistance upon reexposure to that pathogen. In the pulmonary system, T[SUB]RM[/SUB] are identified through S1P antagonist CD69 and expression of integrins CD103/β7 and CD49a/CD29(β1). Contrary to the established role of CD69 on CD8 T cells, the functions of CD103 and CD49a on this population are not well defined. This study examines the expression patterns and functions of CD103 and CD49a with a specific focus on their impact on T cell motility during influenza virus infection. We show that the T[SUB]RM[/SUB] cell surface phenotype develops by 2 wk postinfection, with the majority of the population expressing CD49a and a subset that is also positive for CD103. Despite a previously established role in retaining T[SUB]RM[/SUB] in peripheral tissues, CD49a facilitates locomotion of virus-specific CD8 T cells, both in vitro and in vivo. These results demonstrate that CD49a may contribute to local surveillance mechanisms of the T[SUB]RM[/SUB] population.
Keywords: T cell; influenza; integrin; memory.
Copyright ? 2020 the Author(s). Published by PNAS.