Proc Natl Acad Sci U S A . A single-shot vaccine approach for the universal influenza A vaccine candidate M2e

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Proc Natl Acad Sci U S A


. 2022 Mar 29;119(13):e2025607119.
doi: 10.1073/pnas.2025607119. Epub 2022 Mar 23.
A single-shot vaccine approach for the universal influenza A vaccine candidate M2e


Ranmali Kavishna[SUP] 1 2 [/SUP], Tha Yang Kang[SUP] 1 2 [/SUP], Maurizio Vacca[SUP] 1 2 [/SUP], Benson Yen Leong Chua[SUP] 2 [/SUP], Hae-Young Park[SUP] 3 [/SUP], Peck Szee Tan[SUP] 3 [/SUP], Vincent Tk Chow[SUP] 1 [/SUP], Mireille H Lahoud[SUP] 3 [/SUP], Sylvie Alonso[SUP] 1 2 [/SUP]



Affiliations

• PMID: 35320040
• DOI: 10.1073/pnas.2025607119

Abstract

SignificanceAlthough the need for a universal influenza vaccine has long been recognized, only a handful of candidates have been identified so far, with even fewer advancing in the clinical pipeline. The 24-amino acid ectodomain of M2 protein (M2e) has been developed over the past two decades. However, M2e-based vaccine candidates have shortcomings, including the need for several administrations and the lack of sustained antibody titers over time. We report here a vaccine targeting strategy that has the potential to confer sustained and strong protection upon a single shot of a small amount of M2e antigen. The current COVID-19 pandemic has highlighted the importance of developing versatile, powerful platforms for the rapid deployment of vaccines against any incoming threat.

Keywords: Clec9A; M2e; single shot; universal influenza A vaccine.