tetano
Editor, Senior Moderator
Nutrients. 2019 Dec 18;12(1). pii: E4. doi: 10.3390/nu12010004. [h=1]Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial.[/h]
Furushima D[SUP]1[/SUP], Nishimura T[SUP]1[/SUP], Takuma N[SUP]2[/SUP], Iketani R[SUP]1[/SUP], Mizuno T[SUP]3[/SUP], Matsui Y[SUP]3[/SUP], Yamaguchi T[SUP]4[/SUP], Nakashima Y[SUP]5[/SUP], Yamamoto S[SUP]5[/SUP], Hibi M[SUP]3[/SUP], Yamada H[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. 2 White Cross Nursing Home, Tokyo 189-0021, Japan. 3 Biological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan. 4 Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan. 5 Personal Healthcare Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
[h=3]Abstract[/h] Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test, p = 0.042). The hazard ratio (95% confidence interval (CI)) with reference to the placebo group was 1.09 (0.61-1.92) in the low-catechin group and 0.46 (0.23-0.95) in the high-catechin group. These findings suggest that catechins combined with xanthan gum protect against URTIs.
[h=4]KEYWORDS:[/h] acute upper respiratory infection; catechins; epigallocatechin gallate; influenza like illness; randomized controlled trial
PMID: 31861349 DOI: 10.3390/nu12010004
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Furushima D[SUP]1[/SUP], Nishimura T[SUP]1[/SUP], Takuma N[SUP]2[/SUP], Iketani R[SUP]1[/SUP], Mizuno T[SUP]3[/SUP], Matsui Y[SUP]3[/SUP], Yamaguchi T[SUP]4[/SUP], Nakashima Y[SUP]5[/SUP], Yamamoto S[SUP]5[/SUP], Hibi M[SUP]3[/SUP], Yamada H[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. 2 White Cross Nursing Home, Tokyo 189-0021, Japan. 3 Biological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan. 4 Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan. 5 Personal Healthcare Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
[h=3]Abstract[/h] Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test, p = 0.042). The hazard ratio (95% confidence interval (CI)) with reference to the placebo group was 1.09 (0.61-1.92) in the low-catechin group and 0.46 (0.23-0.95) in the high-catechin group. These findings suggest that catechins combined with xanthan gum protect against URTIs.
[h=4]KEYWORDS:[/h] acute upper respiratory infection; catechins; epigallocatechin gallate; influenza like illness; randomized controlled trial
PMID: 31861349 DOI: 10.3390/nu12010004
Free full text