tetano
Editor, Senior Moderator
Clin Infect Dis. 2015 Feb 11. pii: civ065. [Epub ahead of print]
[h=1]Prevalence and incidence of respiratory syncytial virus and other respiratory viral infections in children 6 months to 10 years of age with influenza-like illness enrolled in a randomized trial.[/h] Nolan T[SUP]1[/SUP], Borja-Tabora C[SUP]2[/SUP], Lopez P[SUP]3[/SUP], Weckx L[SUP]4[/SUP], Ulloa-Gutierrez R[SUP]5[/SUP], Lazcano-Ponce E[SUP]6[/SUP], Kerdpanich A[SUP]7[/SUP], Rodriguez Weber MA[SUP]8[/SUP], de Los Santos AM[SUP]9[/SUP], Tinoco JC[SUP]10[/SUP], Safadi MA[SUP]11[/SUP], Fong Seng L[SUP]12[/SUP], Hernandez-de Mezerville M[SUP]13[/SUP], Faingezicht I[SUP]5[/SUP], Cruz-Valdez A[SUP]6[/SUP], Feng Y[SUP]13[/SUP], Li P[SUP]14[/SUP], Durviaux S[SUP]13[/SUP], Haars G[SUP]13[/SUP], Roy-Ghanta S[SUP]14[/SUP], Vaughn DW[SUP]15[/SUP], Taylor S[SUP]13[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h]
[h=4]RESULTS:[/h] 6266 children were included, of whom 2421 experienced 3717 ILI episodes with a respiratory sample available. RSV was detected for 359 ILI episodes, a prevalence of 9.7% (95% CI: 8.7-10.7). The highest prevalence was in children aged 12-23 or 24-35 months in all countries except the Philippines, where it was in children aged 6-11 months. The incidence of RSV-associated ILI was 7.0 (6.3-7.7) per 100 person-years. Eighty-eight ILI episodes resulted in hospitalization, of which eight were associated with RSV (prevalence 9.1% [4.0-17.1]; incidence 0.2 [0.1-0.3] per 100 person-years). The incidence of RSV-associated ILI resulting in medical attendance was 6.0 (5.4-6.7) per 100 person-years. RSV B subtypes were observed more frequently than A subtypes.
[h=4]CONCLUSIONS:[/h] Active surveillance demonstrated the considerable burden of RSV-associated illness that would not be identified through hospital-based surveillance, with a substantial part of the burden occurring in older infants and children.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
PMID: 25673560 [PubMed - as supplied by publisher]
[h=1]Prevalence and incidence of respiratory syncytial virus and other respiratory viral infections in children 6 months to 10 years of age with influenza-like illness enrolled in a randomized trial.[/h] Nolan T[SUP]1[/SUP], Borja-Tabora C[SUP]2[/SUP], Lopez P[SUP]3[/SUP], Weckx L[SUP]4[/SUP], Ulloa-Gutierrez R[SUP]5[/SUP], Lazcano-Ponce E[SUP]6[/SUP], Kerdpanich A[SUP]7[/SUP], Rodriguez Weber MA[SUP]8[/SUP], de Los Santos AM[SUP]9[/SUP], Tinoco JC[SUP]10[/SUP], Safadi MA[SUP]11[/SUP], Fong Seng L[SUP]12[/SUP], Hernandez-de Mezerville M[SUP]13[/SUP], Faingezicht I[SUP]5[/SUP], Cruz-Valdez A[SUP]6[/SUP], Feng Y[SUP]13[/SUP], Li P[SUP]14[/SUP], Durviaux S[SUP]13[/SUP], Haars G[SUP]13[/SUP], Roy-Ghanta S[SUP]14[/SUP], Vaughn DW[SUP]15[/SUP], Taylor S[SUP]13[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h]
[h=4]RESULTS:[/h] 6266 children were included, of whom 2421 experienced 3717 ILI episodes with a respiratory sample available. RSV was detected for 359 ILI episodes, a prevalence of 9.7% (95% CI: 8.7-10.7). The highest prevalence was in children aged 12-23 or 24-35 months in all countries except the Philippines, where it was in children aged 6-11 months. The incidence of RSV-associated ILI was 7.0 (6.3-7.7) per 100 person-years. Eighty-eight ILI episodes resulted in hospitalization, of which eight were associated with RSV (prevalence 9.1% [4.0-17.1]; incidence 0.2 [0.1-0.3] per 100 person-years). The incidence of RSV-associated ILI resulting in medical attendance was 6.0 (5.4-6.7) per 100 person-years. RSV B subtypes were observed more frequently than A subtypes.
[h=4]CONCLUSIONS:[/h] Active surveillance demonstrated the considerable burden of RSV-associated illness that would not be identified through hospital-based surveillance, with a substantial part of the burden occurring in older infants and children.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
PMID: 25673560 [PubMed - as supplied by publisher]